intercalated cell | definition

specialized cell of the collecting ducts that secrete or absorb acid or bicarbonate; important in acid-base balance


Betts, J. G., Young, K. A., Wise, J. A., Johnson, E., Poe, B., Kruse, D. H., … DeSaix, P. (n.d.). Anatomy and Physiology. Houston, Texas: OpenStax. Access for free at:

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Research Articles Related To Intercalated Cell

Research Article: Colocalization of the (Pro)renin Receptor/Atp6ap2 with H+-ATPases in Mouse Kidney but Prorenin Does Not Acutely Regulate Intercalated Cell H+-ATPase Activity

Date Published: January 29, 2016 Publisher: Public Library of Science Author(s): Arezoo Daryadel, Soline Bourgeois, Marta F. L. Figueiredo, Ana Gomes Moreira, Nicole B. Kampik, Lisa Oberli, Nilufar Mohebbi, Xifeng Lu, Marcel E. Meima, A. H. Jan Danser, Carsten A. Wagner, Dimitrios Fotiadis. Abstract The (Pro)renin receptor (P)RR/Atp6ap2 is a cell surface protein capable … Continue reading

Research Article: Renal Type A Intercalated Cells Contain Albumin in Organelles with Aldosterone-Regulated Abundance

Date Published: April 13, 2015 Publisher: Public Library of Science Author(s): Thomas Buus Jensen, Muhammad Umar Cheema, Agata Szymiczek, Helle Hasager Damkier, Jeppe Praetorius, Franziska Theilig. Abstract Albumin has been identified in preparations of renal distal tubules and collecting ducts by mass spectrometry. This study aimed to establish whether albumin was a contaminant in … Continue reading

Research Article: Renal Intercalated Cells Sense and Mediate Inflammation via the P2Y14 Receptor

Date Published: March 23, 2015 Publisher: Public Library of Science Author(s): Anie Azroyan, Virna Cortez-Retamozo, Richard Bouley, Rachel Liberman, Ye Chun Ruan, Evgeny Kiselev, Kenneth A. Jacobson, Mikael J. Pittet, Dennis Brown, Sylvie Breton, Niels Olsen Saraiva Câmara. Abstract Uncontrolled inflammation is one of the leading causes of kidney failure. Pro-inflammatory responses can occur … Continue reading

Research Article: Endogenous Retinoic Acid Activity in Principal Cells and Intercalated Cells of Mouse Collecting Duct System

Date Published: February 4, 2011 Publisher: Public Library of Science Author(s): Yuen Fei Wong, Jeffrey B. Kopp, Catherine Roberts, Peter J. Scambler, Yoshifusa Abe, Alexandra C. Rankin, Neelanjana Dutt, Bruce M. Hendry, Qihe Xu, Jean-Claude Dussaule. Abstract: Retinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by … Continue reading

Research Article: TSS-Seq analysis of low pH-induced gene expression in intercalated cells in the renal collecting duct

Date Published: August 31, 2017 Publisher: Public Library of Science Author(s): Yuichiro Izumi, Hideki Inoue, Yushi Nakayama, Koji Eguchi, Yukiko Yasuoka, Naomi Matsuo, Hiroshi Nonoguchi, Yutaka Kakizoe, Takashige Kuwabara, Masashi Mukoyama, Jeff M Sands. Abstract Metabolic acidosis often results from chronic kidney disease; in turn, metabolic acidosis accelerates the progression of kidney injury. The … Continue reading

Research Article: Direct Physical Contact between Intercalated Cells in the Distal Convoluted Tubule and the Afferent Arteriole in Mouse Kidneys

Date Published: September 5, 2013 Publisher: Public Library of Science Author(s): Hao Ren, Ning-Yu Liu, Arne Andreasen, Jesper S. Thomsen, Liu Cao, Erik I. Christensen, Xiao-Yue Zhai, Jian Fu. Abstract Recent physiological studies in the kidney proposed the existence of a secondary feedback mechanism termed ‘crosstalk’ localized after the macula densa. This newly discovered … Continue reading


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