islets of Langerhans | definition

endocrine cells of the pancreas


Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at:


Research Article: Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans

Date Published: May 30, 2013 Publisher: Public Library of Science Author(s): Mijke Buitinga, Roman Truckenmüller, Marten A. Engelse, Lorenzo Moroni, Hetty W. M. Ten Hoopen, Clemens A. van Blitterswijk, Eelco JP. de Koning, Aart A. van Apeldoorn, Marcel Karperien, Masaya Yamamoto. Abstract: Allogeneic islet transplantation into the liver has the potential to restore normoglycemia in … Continue reading

Research Article: Label-Free Detection of Insulin and Glucagon within Human Islets of Langerhans Using Raman Spectroscopy

Date Published: October 22, 2013 Publisher: Public Library of Science Author(s): Janneke Hilderink, Cees Otto, Cees Slump, Aufried Lenferink, Marten Engelse, Clemens van Blitterswijk, Eelco de Koning, Marcel Karperien, Aart van Apeldoorn, Andrea Vergani. Abstract: Intrahepatic transplantation of donor islets of Langerhans is a promising therapy for patients with type 1 diabetes. It is … Continue reading

Research Article: Glucose-Stimulated Calcium Dynamics in Islets of Langerhans in Acute Mouse Pancreas Tissue Slices

Date Published: January 24, 2013 Publisher: Public Library of Science Author(s): Andraž Stožer, Jurij Dolenšek, Marjan Slak Rupnik, Kathrin Maedler. Abstract: In endocrine cells within islets of Langerhans calcium ions couple cell stimulation to hormone secretion. Since the advent of modern fluorimetry, numerous in vitro studies employing primarily isolated mouse islets have investigated the effects … Continue reading

Research Article: Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β

Date Published: February 8, 2012 Publisher: Public Library of Science Author(s): Sergi Soriano, Paloma Alonso-Magdalena, Marta García-Arévalo, Anna Novials, Sarheed J. Muhammed, Albert Salehi, Jan-Ake Gustafsson, Ivan Quesada, Angel Nadal, Kathrin Maedler. Abstract: Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. It alters pancreatic … Continue reading

Research Article: The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans

Date Published: August 12, 2015 Publisher: Public Library of Science Author(s): Deborah A. Striegel, Manami Hara, Vipul Periwal, Morten Gram Pedersen Abstract: Pancreatic islets of Langerhans consist of endocrine cells, primarily α, β and δ cells, which secrete glucagon, insulin, and somatostatin, respectively, to regulate plasma glucose. β cells form irregular locally connected clusters within … Continue reading

Research Article: Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices

Date Published: February 28, 2013 Publisher: Public Library of Science Author(s): Andraž Stožer, Marko Gosak, Jurij Dolenšek, Matjaž Perc, Marko Marhl, Marjan Slak Rupnik, Dean Korošak, Stanislav Shvartsman Abstract: We propose a network representation of electrically coupled beta cells in islets of Langerhans. Beta cells are functionally connected on the basis of correlations between calcium … Continue reading

Research Article: Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

Date Published: April 27, 2012 Publisher: Public Library of Science Author(s): Julie Amyot, Meriem Semache, Mourad Ferdaoussi, Ghislaine Fontés, Vincent Poitout, Orian S. Shirihai. Abstract: Type 2 diabetes is characterized by pancreatic β-cell dysfunction and is associated with low-grade inflammation. Recent observations suggest that the signalling cascade activated by lipopolysaccharides (LPS) binding to Toll-Like Receptor … Continue reading

Research Article: A KATP Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

Date Published: June 15, 2007 Publisher: Public Library of Science Author(s): Patrick E MacDonald, Yang Zhang De Marinis, Reshma Ramracheya, Albert Salehi, Xiaosong Ma, Paul R. V Johnson, Roger Cox, Lena Eliasson, Patrik Rorsman, Antonio J Vidal-Puig Abstract: Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon … Continue reading

Research Article: Gliadin Fragments and a Specific Gliadin 33-mer Peptide Close KATP Channels and Induce Insulin Secretion in INS-1E Cells and Rat Islets of Langerhans

Date Published: June 13, 2013 Publisher: Public Library of Science Author(s): Morten Dall, Kirstine Calloe, Martin Haupt-Jorgensen, Jesper Larsen, Nicole Schmitt, Knud Josefsen, Karsten Buschard, Matthias G. von Herrath. Abstract: In non-obese diabetic (NOD) mice, diabetes incidence is reduced by a gluten-free diet. Gluten peptides, such as the compound gliadin, can cross the intestinal barrier … Continue reading

Research Article: Regional Differences in Islet Distribution in the Human Pancreas – Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes

Date Published: June 24, 2013 Publisher: Public Library of Science Author(s): Xiaojun Wang, Ryosuke Misawa, Mark C. Zielinski, Peter Cowen, Junghyo Jo, Vipul Periwal, Camillo Ricordi, Aisha Khan, Joel Szust, Junhui Shen, J. Michael Millis, Piotr Witkowski, Manami Hara, Thomas W H. Kay. Abstract: While regional heterogeneity in islet distribution has been well studied … Continue reading