mesangial cells | definition

  • contractile cells found in the glomerulus
  • can contract or relax to regulate filtration rate


Betts, J. G., Young, K. A., Wise, J. A., Johnson, E., Poe, B., Kruse, D. H., … DeSaix, P. (n.d.). Anatomy and Physiology. Houston, Texas: OpenStax. Access for free at:

Keywords: definition, define, what is, meaning, thesaurus, synonyms, dictionary, encyclopedia, research, research article, research study, scientific literature, science topic

Research Articles Related To Mesangial Cells

Research Article: Unique Regulatory Properties of Mesangial Cells Are Genetically Determined in the Rat

Date Published: October 24, 2014 Publisher: Public Library of Science Author(s): Ping-Chin Lai, Ling-Yin Chiu, Prashant Srivastava, Cristina Trento, Francesco Dazzi, Enrico Petretto, H. Terence Cook, Jacques Behmoaras, Niels Olsen Saraiva Câmara. Abstract Mesangial cells are glomerular cells of stromal origin. During immune complex mediated crescentic glomerulonephritis (Crgn), infiltrating and proliferating pro-inflammatory macrophages lead … Continue reading

Research Article: Sodium Glucose Cotransporter 2 (SGLT2) Plays as a Physiological Glucose Sensor and Regulates Cellular Contractility in Rat Mesangial Cells

Date Published: March 21, 2016 Publisher: Public Library of Science Author(s): Masanori Wakisaka, Tetsuhiko Nagao, Mototaka Yoshinari, Utpal Sen. Abstract Mesangial cells play an important role in regulating glomerular filtration by altering their cellular tone. We report the presence of a sodium glucose cotransporter (SGLT) in rat mesangial cells. This study in rat mesangial … Continue reading

Research Article: Synergistic Effect of Mesangial Cell-Induced CXCL1 and TGF-β1 in Promoting Podocyte Loss in IgA Nephropathy

Date Published: August 30, 2013 Publisher: Public Library of Science Author(s): Li Zhu, Qingxian Zhang, Sufang Shi, Lijun Liu, Jicheng Lv, Hong Zhang, Jean-Claude Dussaule. Abstract Podocyte loss has been reported to relate to disease severity and progression in IgA nephropathy (IgAN). However, the underlying mechanism for its role in IgAN remain unclear. Recent … Continue reading

Research Article: X-Linked Alport Dogs Demonstrate Mesangial Filopodial Invasion of the Capillary Tuft as an Early Event in Glomerular Damage

Date Published: December 13, 2016 Publisher: Public Library of Science Author(s): Sabrina D. Clark, Mary B. Nabity, Rachel E. Cianciolo, Brianna Dufek, Dominic Cosgrove, Alexander V. Ljubimov. Abstract X-linked Alport syndrome (XLAS), caused by mutations in the type IV collagen COL4A5 gene, accounts for approximately 80% of human Alport syndrome. Dogs with XLAS have … Continue reading

Research Article: A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells

Date Published: August 28, 2019 Publisher: Public Library of Science Author(s): Andrew S. Potter, Keri Drake, Eric W. Brunskill, S. Steven Potter, Peter Hohenstein. Abstract Focal segmental glomerulosclerosis is a major cause of end stage renal disease. Many patients prove unresponsive to available therapies. An improved understanding of the molecular basis of the disease … Continue reading

Research Article: Fenofibrate Attenuated Glucose-Induced Mesangial Cells Proliferation and Extracellular Matrix Synthesis via PI3K/AKT and ERK1/2

Date Published: October 9, 2013 Publisher: Public Library of Science Author(s): Rui Zeng, Yan Xiong, Fengming Zhu, Zufu Ma, Wenhui Liao, Yong He, JinSeng He, Wei Li, Juan Yang, Qian Lu, Gang Xu, Ying Yao, Effie C Tsilibary. Abstract Excess mesangial extracellular matrix (ECM) and mesangial cell proliferation is the major pathologic feature of diabetic … Continue reading

Research Article: Glycoxidised LDL Induced the Upregulation of Axl Receptor Tyrosine Kinase and Its Ligand in Mouse Mesangial Cells

Date Published: November 30, 2012 Publisher: Public Library of Science Author(s): Young Sook Kim, Dong Ho Jung, Eunjin Sohn, Junghyun Kim, Jin Sook Kim, Bridget Wagner. Abstract Low-density lipoprotein (LDL) is subjected to glycoxidation in diabetes, and a novel signalling mechanism by which glycoxidised LDL functions in glomerular mesangial cells remains to be ascertained. We … Continue reading

Research Article: AS101 Prevents Diabetic Nephropathy Progression and Mesangial Cell Dysfunction: Regulation of the AKT Downstream Pathway

Date Published: December 4, 2014 Publisher: Public Library of Science Author(s): Itay Israel Shemesh, Benaya Rozen-Zvi, Yona Kalechman, Uzi Gafter, Benjamin Sredni, Garyfalia Drossopoulou. Abstract Diabetic nephropathy (DN) is characterized by proliferation of mesangial cells, mesangial expansion, hypertrophy and extracellular matrix accumulation. Previous data have cross-linked PKB (AKT) to TGFβ induced matrix modulation. The … Continue reading

Research Article: Emodin Suppresses Hyperglycemia-Induced Proliferation and Fibronectin Expression in Mesangial Cells via Inhibiting cFLIP

Date Published: April 1, 2014 Publisher: Public Library of Science Author(s): Junjie Gao, Fangli Wang, Weisong Wang, Zhiguo Su, Canghui Guo, Shuyi Cao, Raghavan Raju. Abstract As one of the most serious microvascular complications of diabetes and a major cause of end stage renal disease, diabetic nephropathy (DN) is calling for effective treatment strategies. … Continue reading

Research Article: 6-Hydroxyflavone and Derivatives Exhibit Potent Anti-Inflammatory Activity among Mono-, Di- and Polyhydroxylated Flavones in Kidney Mesangial Cells

Date Published: March 19, 2015 Publisher: Public Library of Science Author(s): Xing Wang, Zhiwei Wang, Preetpal Singh Sidhu, Umesh R. Desai, Qibing Zhou, Salvatore V Pizzo. Abstract Inflammatory responses by kidney mesangial cells play a critical role in the glomerulonephritis. The anti-inflammatory potential of nineteen mono-, di- and polyhydroxylated flavones including fisetin, quercetin, morin, … Continue reading


Keywords: define mesangial cells, mesangial cells definition, what are mesangial cells, meaning of mesangial cells, mesangial cells, what are contractile cells in kidney