mitochondrial matrix | definition

  • the innermost space of the mitochondrion enclosed by two membranes
  • the location of many metabolic enzymes as well as the mitochondrial DNA and 70S ribosomes

Source:

Parker, N., Schneegurt, M., Thi Tu, A.-H., Forster, B. M., & Lister, P. (n.d.). Microbiology. Houston, Texas: OpenStax. Access for free at: https://openstax.org/details/books/microbiology


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Research Article: Identification of Mitochondrial DNA Polymorphisms That Alter Mitochondrial Matrix pH and Intracellular Calcium Dynamics

Date Published: August 11, 2006 Publisher: Public Library of Science Author(s): An-a Kazuno, Kae Munakata, Takeharu Nagai, Satoshi Shimozono, Masashi Tanaka, Makoto Yoneda, Nobumasa Kato, Atsushi Miyawaki, Tadafumi Kato, Harry Orr Abstract: Mitochondrial DNA (mtDNA) is highly polymorphic, and its variations in humans may contribute to individual differences in function as well as susceptibility to … Continue readingResearch

Research Article: Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix

Date Published: July 19, 2019 Publisher: Public Library of Science Author(s): Nelson Osuagwu, Christian Dölle, Charalampos Tzoulis, David Chau. http://doi.org/10.1371/journal.pone.0219909 Abstract: Several proteins linked to familial Parkinson disease have been associated with mitochondrial (dys-)function and have been described to reside within mitochondria. The putative mitochondrial and sub-mitochondrial localization of these proteins remains disputed, however, potentially … Continue reading

Research Article: Interaction of Glutaric Aciduria Type 1-Related glutaryl-CoA Dehydrogenase with Mitochondrial Matrix Proteins

Date Published: February 3, 2014 Publisher: Public Library of Science Author(s): Jessica Schmiesing, Hartmut Schlüter, Kurt Ullrich, Thomas Braulke, Chris Mühlhausen, Inês A. Cardoso Pereira. http://doi.org/10.1371/journal.pone.0087715 Abstract: Glutaric aciduria type 1 (GA1) is an inherited neurometabolic disorder caused by mutations in the GCDH gene encoding glutaryl-CoA dehydrogenase (GCDH), which forms homo- and heteromeric complexes in … Continue reading

Research Article: PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix

Date Published: May 29, 2014 Publisher: Public Library of Science Author(s): Ruth E. Thomas, Laurie A. Andrews, Jonathon L. Burman, Wen-Yang Lin, Leo J. Pallanck, Alex van der Bliek Abstract: Loss-of-function mutations in PINK1, which encodes a mitochondrially targeted serine/threonine kinase, result in an early-onset heritable form of Parkinson’s disease. Previous work has shown that … Continue reading

Research Article: Evidence of Evolutionary Constraints That Influences the Sequence Composition and Diversity of Mitochondrial Matrix Targeting Signals

Date Published: June 25, 2013 Publisher: Public Library of Science Author(s): Stephen R. Doyle, Naga R. P. Kasinadhuni, Chee Kai Chan, Warwick N. Grant, Niall James Haslam. http://doi.org/10.1371/journal.pone.0067938 Abstract: Mitochondrial targeting signals (MTSs) are responsible for trafficking nuclear encoded proteins to their final destination within mitochondria. These sequences are diverse, sharing little amino acid homology … Continue reading


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