nephrons | definition

  • functional units of the kidney that carry out all filtration and modification to produce urine
  • consist of renal corpuscles, proximal and distal convoluted tubules, and descending and ascending loops of Henle
  • drain into collecting ducts


Betts, J. G., Young, K. A., Wise, J. A., Johnson, E., Poe, B., Kruse, D. H., … DeSaix, P. (n.d.). Anatomy and Physiology. Houston, Texas: OpenStax. Access for free at:

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Research Articles Related To Nephrons

Research Article: MITF – A controls branching morphogenesis and nephron endowment

Date Published: December 14, 2017 Publisher: Public Library of Science Author(s): Aurélie Phelep, Denise Laouari, Kapil Bharti, Martine Burtin, Salvina Tammaccaro, Serge Garbay, Clément Nguyen, Florence Vasseur, Thomas Blanc, Sophie Berissi, Francina Langa-Vives, Evelyne Fischer, Anne Druilhe, Heinz Arnheiter, Gerard Friedlander, Marco Pontoglio, Fabiola Terzi, Andreas Schedl Abstract: Congenital nephron number varies widely in the … Continue reading

Research Article: Collective Cell Migration Drives Morphogenesis of the Kidney Nephron

Date Published: January 6, 2009 Publisher: Public Library of Science Author(s): Aleksandr Vasilyev, Yan Liu, Sudha Mudumana, Steve Mangos, Pui-Ying Lam, Arindam Majumdar, Jinhua Zhao, Kar-Lai Poon, Igor Kondrychyn, Vladimir Korzh, Iain A Drummond, Derek L Stemple Abstract: Tissue organization in epithelial organs is achieved during development by the combined processes of cell differentiation and … Continue reading

Research Article: Maternal Fat Feeding Augments Offspring Nephron Endowment in Mice

Date Published: August 22, 2016 Publisher: Public Library of Science Author(s): Stacey Hokke, Victor G. Puelles, James A. Armitage, Karen Fong, John F. Bertram, Luise A. Cullen-McEwen, Nick Ashton. Abstract Increasing consumption of a high fat ‘Western’ diet has led to a growing number of pregnancies complicated by maternal obesity. Maternal overnutrition and obesity … Continue reading

Research Article: Compensatory Growth of Congenital Solitary Kidneys in Pigs Reflects Increased Nephron Numbers Rather Than Hypertrophy

Date Published: November 21, 2012 Publisher: Public Library of Science Author(s): Stefan H. van Vuuren, Chalana M. Sol, Roel Broekhuizen, Marc R. Lilien, Michiel J. S. Oosterveld, Tri Q. Nguyen, Roel Goldschmeding, Tom P. V. M. de Jong, Hideharu Abe. Abstract Patients with unilateral MultiCystic Kidney Dysplasia (MCKD) or unilateral renal agenesis (URA) have a … Continue reading

Research Article: A computational model of epithelial solute and water transport along a human nephron

Date Published: February 25, 2019 Publisher: Public Library of Science Author(s): Anita T. Layton, Harold E. Layton, Daniel A Beard Abstract: We have developed the first computational model of solute and water transport from Bowman space to the papillary tip of the nephron of a human kidney. The nephron is represented as a tubule lined … Continue reading

Research Article: Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies

Date Published: January 29, 2018 Publisher: Public Library of Science Author(s): Lori L. O’Brien, Qiuyu Guo, Emad Bahrami-Samani, Joo-Seop Park, Sean M. Hasso, Young-Jin Lee, Alan Fang, Albert D. Kim, Jinjin Guo, Trudy M. Hong, Kevin A. Peterson, Scott Lozanoff, Ramya Raviram, Bing Ren, Ben Fogelgren, Andrew D. Smith, Anton Valouev, Andrew P. McMahon, David … Continue reading

Research Article: Betaglycan Is Required for the Establishment of Nephron Endowment in the Mouse

Date Published: April 18, 2011 Publisher: Public Library of Science Author(s): Kenneth A. Walker, Sunder Sims-Lucas, Georgina Caruana, Luise Cullen-McEwen, Jinhua Li, Mai A. Sarraj, John F. Bertram, Kaye L. Stenvers, Christos Chatziantoniou. Abstract: Betaglycan is an accessory receptor for the transforming growth factor-β (TGFβ) superfamily, many members of which play key roles in kidney … Continue reading


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