oocyte | definition

cell that results from the division of the oogonium and undergoes meiosis I at the luteinizing hormone surge and meiosis II at fertilization to become a haploid ovum


Betts, J. G., Young, K. A., Wise, J. A., Johnson, E., Poe, B., Kruse, D. H., … DeSaix, P. (n.d.). Anatomy and Physiology. Houston, Texas: OpenStax. Access for free at: https://openstax.org/details/books/anatomy-and-physiology

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The Contact Between Sperm and Oocyte

OpenStax Anatomy and Physiology. Upon ovulation, the oocyte released by the ovary is swept into—and along—the uterine tube. Fertilization must occur in the distal uterine tube because an unfertilized oocyte cannot survive the 72-hour journey to the uterus. As you will recall from your study of the oogenesis, this oocyte (specifically a secondary oocyte) is … Continue reading

Research Article: Diffused Intra-Oocyte Hydrogen Peroxide Activates Myeloperoxidase and Deteriorates Oocyte Quality

Date Published: July 21, 2015 Publisher: Public Library of Science Author(s): Sana N. Khan, Faten Shaeib, Tohid Najafi, Mahendra Kavdia, Bernard Gonik, Ghassan M. Saed, Pravin T. Goud, Husam M. Abu-Soud, Meijia Zhang. http://doi.org/10.1371/journal.pone.0132388 Abstract: Hydrogen peroxide (H2O2) is a relatively long-lived signaling molecule that plays an essential role in oocyte maturation, implantation, as well … Continue reading

Research Article: Hydrogen Sulfide Donor Protects Porcine Oocytes against Aging and Improves the Developmental Potential of Aged Porcine Oocytes

Date Published: January 23, 2015 Publisher: Public Library of Science Author(s): Tereza Krejcova, Miroslava Smelcova, Jaroslav Petr, Jean-Francois Bodart, Marketa Sedmikova, Jan Nevoral, Marketa Dvorakova, Alena Vyskocilova, Ivona Weingartova, Veronika Kucerova-Chrpova, Eva Chmelikova, Lenka Tumova, Frantisek Jilek, Qing-Yuan Sun. http://doi.org/10.1371/journal.pone.0116964 Abstract: Porcine oocytes that have matured in in vitro conditions undergo the process of aging … Continue reading

Research Article: DNA Double-Strand Breaks Induce the Nuclear Actin Filaments Formation in Cumulus-Enclosed Oocytes but Not in Denuded Oocytes

Date Published: January 18, 2017 Publisher: Public Library of Science Author(s): Ming-Hong Sun, Mo Yang, Feng-Yun Xie, Wei Wang, Lili Zhang, Wei Shen, Shen Yin, Jun-Yu Ma, Qing-Yuan Sun. http://doi.org/10.1371/journal.pone.0170308 Abstract: As a gamete, oocyte needs to maintain its genomic integrity and passes this haploid genome to the next generation. However, fully-grown mouse oocyte cannot … Continue reading

Research Article: Mitogenomes of Polar Bodies and Corresponding Oocytes

Date Published: July 17, 2014 Publisher: Public Library of Science Author(s): Luca Gianoarli, Donata Luiselli, Anna Maria Crivello, Martin Lang, Anna Pia Ferraretti, Sara De Fanti, M. Cristina Magli, Giovanni Romeo, Qing-Yuan Sun. http://doi.org/10.1371/journal.pone.0102182 Abstract: The objective of the present study was to develop an approach that could assess the chromosomal status and the mitochondrial … Continue reading

Research Article: In Vitro Maturation of Cumulus-Oocyte Complexes for Efficient Isolation of Oocytes from Outbred Deer Mice

Date Published: February 14, 2013 Publisher: Public Library of Science Author(s): Jung Kyu Choi, Xiaoming He, Colette Kanellopoulos-Langevin. http://doi.org/10.1371/journal.pone.0056158 Abstract: The outbred (as with humans) deer mice have been a useful animal model of research on human behavior and biology including that of the reproductive system. One of the major challenges in using this species is … Continue reading

Research Article: Glycolytic Metabolites Are Critical Modulators of Oocyte Maturation and Viability

Date Published: October 22, 2013 Publisher: Public Library of Science Author(s): Lloyd Berger, Andrew Wilde, Robert E. Steele. http://doi.org/10.1371/journal.pone.0077612 Abstract: The maturation of an oocyte into an egg is a key step in preparation for fertilization. In Xenopus, oocyte maturation is independent of transcription, being regulated at the level of translation and post-translational modifications of proteins. … Continue reading

Research Article: Kif4 Is Essential for Mouse Oocyte Meiosis

Date Published: January 26, 2017 Publisher: Public Library of Science Author(s): Nicole J. Camlin, Eileen A. McLaughlin, Janet E. Holt, Qing-Yuan Sun. http://doi.org/10.1371/journal.pone.0170650 Abstract: Progression through the meiotic cell cycle must be strictly regulated in oocytes to generate viable embryos and offspring. During mitosis, the kinesin motor protein Kif4 is indispensable for chromosome condensation and … Continue reading

Research Article: Control of Oocyte Reawakening by Kit

Date Published: August 8, 2016 Publisher: Public Library of Science Author(s): Hatice Duygu Saatcioglu, Ileana Cuevas, Diego H. Castrillon, Joan Jorgensen Abstract: In mammals, females are born with finite numbers of oocytes stockpiled as primordial follicles. Oocytes are “reawakened” via an ovarian-intrinsic process that initiates their growth. The forkhead transcription factor Foxo3 controls reawakening downstream … Continue reading

Research Article: Apoptosis Maintains Oocyte Quality in Aging Caenorhabditis elegans Females

Date Published: December 5, 2008 Publisher: Public Library of Science Author(s): Sara Andux, Ronald E. Ellis, Susan E. Mango Abstract: In women, oocytes arrest development at the end of prophase of meiosis I and remain quiescent for years. Over time, the quality and quantity of these oocytes decreases, resulting in fewer pregnancies and an increased … Continue reading