osteomalacia | definition

  • softening of bones due to a lack of mineralization with calcium and phosphate
  • usually due to lack of vitamin D
  • in children, osteomalacia is termed rickets


Betts, J. G., Young, K. A., Wise, J. A., Johnson, E., Poe, B., Kruse, D. H., … DeSaix, P. (n.d.). Anatomy and Physiology. Houston, Texas: OpenStax. Access for free at: https://openstax.org/details/books/anatomy-and-physiology



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Research Article: Identification of Two Novel Mutations in the PHEX Gene in Chinese Patients with Hypophosphatemic Rickets/Osteomalacia

Date Published: May 16, 2014 Publisher: Public Library of Science Author(s): Hua Yue, Jin-bo Yu, Jin-wei He, Zeng Zhang, Wen-zhen Fu, Hao Zhang, Chun Wang, Wei-wei Hu, Jie-mei Gu, Yun-qiu Hu, Miao Li, Yu-juan Liu, Zhen-Lin Zhang, Klaus Brusgaard. http://doi.org/10.1371/journal.pone.0097830 X-linked dominant hypophosphatemia (XLH) is the most prevalent form of inherited rickets/osteomalacia in humans. … Continue reading

Research Article: Is Gastrectomy-Induced High Turnover of Bone with Hyperosteoidosis and Increase of Mineralization a Typical Osteomalacia?

Date Published: June 11, 2013 Publisher: Public Library of Science Author(s): Takashi Ueyama, Yuta Yamamoto, Kazuki Ueda, Aiji Yajima, Yoshimasa Maeda, Yasunobu Yamashita, Takao Ito, Yoshihiro Tsuruo, Masao Ichinose, Brenda Smith. http://doi.org/10.1371/journal.pone.0065685 Gastrectomy (GX) is thought to result in osteomalacia due to deficiencies in Vitamin D and Ca. Using a GX rat model, we showed … Continue reading

Research Article: Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up

Date Published: May 17, 2017 Publisher: Public Library of Science Author(s): Wei Zhu, Qi Ma, Yanyan Bian, Qianyu Zhuang, Zenan Xia, Jin Jin, Xisheng Weng, Chunfeng Zhao. http://doi.org/10.1371/journal.pone.0177835 Tumor-induced osteomalacia (TIO) may result in a better prognosis after complete resection of the causative neoplasm. However, tumors located proximal to the articular surface of the … Continue reading



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