Research Article: The NADPH Oxidase Nox4 and Aging in the Heart

Date Published: December 27, 2010 Publisher: Impact Journals LLC Author(s): Tetsuro Ago, Shouji Matsushima, Junya Kuroda, Daniela Zablocki, Takanari Kitazono, Junichi Sadoshima. http:// Abstract Oxidative stress in mitochondria is believed to promote aging. Although passive leakage of electron from the mitochondrial electron transport chain has been considered as a major source of oxidative stress in … Continue reading Research Article: The NADPH Oxidase Nox4 and Aging in the Heart

Research Article: Surprising sirtuin crosstalk in the heart

Date Published: March 17, 2010 Publisher: Impact Journals LLC Author(s): Thaddeus T. Schug, Xiaoling Li. http:// Abstract Partial Text A study by Vinciguerra et al. published in the January 2010 issue of Aging furnishes new and important information about the cellular mechanisms leading to the pathogenesis of heart failure [22]. They propose a cardioprotective link … Continue reading Research Article: Surprising sirtuin crosstalk in the heart

Research Article: A System for Heart Sounds Classification

Date Published: November 13, 2014 Publisher: Public Library of Science Author(s): Grzegorz Redlarski, Dawid Gradolewski, Aleksander Palkowski, Alena Talkachova. http://doi.org/10.1371/journal.pone.0112673 Abstract The future of quick and efficient disease diagnosis lays in the development of reliable non-invasive methods. As for the cardiac diseases – one of the major causes of death around the globe – a … Continue reading Research Article: A System for Heart Sounds Classification

Research Article: The effect of Tmem135 overexpression on the mouse heart

Date Published: August 13, 2018 Publisher: Public Library of Science Author(s): Sarah Aileen Lewis, Tetsuya Takimoto, Shima Mehrvar, Hitoshi Higuchi, Anna-Lisa Doebley, Giangela Stokes, Nader Sheibani, Sakae Ikeda, Mahsa Ranji, Akihiro Ikeda, Guo-Chang Fan. http://doi.org/10.1371/journal.pone.0201986 Abstract Tissues with high-energy demand including the heart are rich in the energy-producing organelles, mitochondria, and sensitive to mitochondrial dysfunction. … Continue reading Research Article: The effect of Tmem135 overexpression on the mouse heart

Research Article: ACE phenotyping in human heart

Date Published: August 3, 2017 Publisher: Public Library of Science Author(s): Victoria E. Tikhomirova, Olga A. Kost, Olga V. Kryukova, Elena Z. Golukhova, Naida I. Bulaeva, Aigerim Z. Zholbaeva, Leo A. Bokeria, Joe G. N. Garcia, Sergei M. Danilov, Michael Bader. http://doi.org/10.1371/journal.pone.0181976 Abstract Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role … Continue reading Research Article: ACE phenotyping in human heart

Research Article: ACE phenotyping in human heart

Date Published: August 3, 2017 Publisher: Public Library of Science Author(s): Victoria E. Tikhomirova, Olga A. Kost, Olga V. Kryukova, Elena Z. Golukhova, Naida I. Bulaeva, Aigerim Z. Zholbaeva, Leo A. Bokeria, Joe G. N. Garcia, Sergei M. Danilov, Michael Bader. http://doi.org/10.1371/journal.pone.0181976 Abstract Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role … Continue reading Research Article: ACE phenotyping in human heart

Research Article: Heterogeneity of T-Tubules in Pig Hearts

Date Published: June 9, 2016 Publisher: Public Library of Science Author(s): Hanne C. Gadeberg, Richard C. Bond, Cherrie H. T. Kong, Guillaume P. Chanoit, Raimondo Ascione, Mark B. Cannell, Andrew F. James, Vincenzo Lionetti. http://doi.org/10.1371/journal.pone.0156862 Abstract T-tubules are invaginations of the sarcolemma that play a key role in excitation-contraction coupling in mammalian cardiac myocytes. Although … Continue reading Research Article: Heterogeneity of T-Tubules in Pig Hearts

Research Article: The Emperor’s New Clothes: PDE5 and the Heart

Date Published: March 6, 2015 Publisher: Public Library of Science Author(s): Chantal V. Degen, Kalkidan Bishu, Rosita Zakeri, Ozgur Ogut, Margaret M. Redfield, Frank V. Brozovich, Rakesh Kukreja. http://doi.org/10.1371/journal.pone.0118664 Abstract Phosphodiesterase-5 (PDE5) is highly expressed in the pulmonary vasculature, but its expression in the myocardium is controversial. Cyclic guanosine monophosphate (cGMP) activates protein kinase G … Continue reading Research Article: The Emperor’s New Clothes: PDE5 and the Heart

Research Article: Modelling Heart Rate Kinetics

Date Published: April 13, 2015 Publisher: Public Library of Science Author(s): Maria S. Zakynthinaki. http://doi.org/10.1371/journal.pone.0118263 Abstract The objective of the present study was to formulate a simple and at the same time effective mathematical model of heart rate kinetics in response to movement (exercise). Based on an existing model, a system of two coupled differential … Continue reading Research Article: Modelling Heart Rate Kinetics

Research Article: ILK Induces Cardiomyogenesis in the Human Heart

Date Published: May 29, 2012 Publisher: Public Library of Science Author(s): Alexandra Traister, Shabana Aafaqi, Stephane Masse, Xiaojing Dai, Mark Li, Aleksander Hinek, Kumaraswamy Nanthakumar, Gregory Hannigan, John G. Coles, Costanza Emanueli. http://doi.org/10.1371/journal.pone.0037802 Abstract Integrin-linked kinase (ILK) is a widely conserved serine/threonine kinase that regulates diverse signal transduction pathways implicated in cardiac hypertrophy and contractility. In … Continue reading Research Article: ILK Induces Cardiomyogenesis in the Human Heart