Permeability of the Lipid Bilayer


Related Posts:

Permeability of the Lipid Bilayer (Campbell Biology)

Non-polar molecules, such as hydrocarbons, CO2, and O2, are hydrophobic, as are lipids. They can all therefore dissolve in the lipid bilayer of the membrane and cross it easily, without the aid of membrane proteins. However, the hydrophobic interior of the membrane impedes direct passage through the membrane of ions and polar molecules, which are hydrophilic. Polar molecules such as glucose and other sugars pass only slowly through a lipid bilayer, and even water, a very small polar molecule, does not cross rapidly relative to non-polar molecules. A charged atom or molecule and its surrounding shell of water are even less likely to penetrate the hydrophobic interior of the membrane. Furthermore, the lipid bilayer is only one aspect of the gatekeeper system responsible for a cell’s selective permeability. Proteins built into the membrane play key roles in regulating transport.


Urry, Lisa A.. Campbell Biology. Pearson Education. Kindle Edition.


Related Research

Research Article: Triglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes

Date Published: September 22, 2010 Publisher: Public Library of Science Author(s): Himanshu Khandelia, Lars Duelund, Kirsi I. Pakkanen, John H. Ipsen, Darren R. Flower. Abstract: Triglycerides have a limited solubility, around 3%, in phosphatidylcholine lipid bilayers. Using millisecond-scale course grained molecular dynamics simulations, we show that the model lipid bilayer can accommodate a higher concentration … Continue reading

Research Article: Design and Characterization of a Membrane Protein Unfolding Platform in Lipid Bilayers

Date Published: March 23, 2015 Publisher: Public Library of Science Author(s): Vincent G. Nadeau, Anqi Gao, Charles M. Deber, Jeffrey L Brodsky. Abstract: Accurate measurement of membrane protein stability—and particularly how it may vary as a result of disease-phenotypic mutations—ideally requires a denaturant that can unfold a membrane-embedded structure while leaving the solubilizing environment … Continue reading

Research Article: A Portable Lipid Bilayer System for Environmental Sensing with a Transmembrane Protein

Date Published: July 29, 2014 Publisher: Public Library of Science Author(s): Ryuji Kawano, Yutaro Tsuji, Koki Kamiya, Taiga Kodama, Toshihisa Osaki, Norihisa Miki, Shoji Takeuchi, Arum Han. Abstract: This paper describes a portable measurement system for current signals of an ion channel that is composed of a planar lipid bilayer. A stable and reproducible … Continue reading

Research Article: Formation and Characterization of Supported Lipid Bilayers Composed of Hydrogenated and Deuterated Escherichia coli Lipids

Date Published: December 11, 2015 Publisher: Public Library of Science Author(s): Tania Kjellerup Lind, Hanna Wacklin, Jürgen Schiller, Martine Moulin, Michael Haertlein, Thomas Günther Pomorski, Marité Cárdenas, Paul J Atzberger. Abstract: Supported lipid bilayers are widely used for sensing and deciphering biomolecular interactions with model cell membranes. In this paper, we present a method … Continue reading

Research Article: Aggregation of Lipid-Anchored Full-Length H-Ras in Lipid Bilayers: Simulations with the MARTINI Force Field

Date Published: July 26, 2013 Publisher: Public Library of Science Author(s): Hualin Li, Alemayehu A. Gorfe, Emanuele Paci. Abstract: Lipid-anchored Ras oncoproteins assemble into transient, nano-sized substructures on the plasma membrane. These substructures, called nanoclusters, were proposed to be crucial for high-fidelity signal transmission in cells. However, the molecular basis of Ras nanoclustering is … Continue reading