phosphodiesterase (PDE) | definition

enzyme that deactivates cyclic AMP, stopping hormone activity


Source:

Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at: https://openstax.org/details/books/biology-2e

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Research Article: Isolation, purification and characterization of 5′-phosphodiesterase from Aspergillus fumigatus

Date Published: October 26, 2017 Publisher: Public Library of Science Author(s): Zhiting Luo, Yingying Fan, Qiuxia Li, Bing Han, Yang Liu, Shubo Li, Hua Qiu, Zongwen Pang, Eugene A. Permyakov. http://doi.org/10.1371/journal.pone.0186011 Abstract: 5′-Phosphodiesterase (5′-PDE) catalyzes the hydrolysis of ribonucleic acid to obtain a mixture of ribonucleotides, such as 5′-guanosine monophosphate and 5′-adenosine monophosphate. In this … Continue reading

Research Article: Isolation, purification and characterization of 5′-phosphodiesterase from Aspergillus fumigatus

Date Published: October 26, 2017 Publisher: Public Library of Science Author(s): Zhiting Luo, Yingying Fan, Qiuxia Li, Bing Han, Yang Liu, Shubo Li, Hua Qiu, Zongwen Pang, Eugene A. Permyakov. http://doi.org/10.1371/journal.pone.0186011 Abstract: 5′-Phosphodiesterase (5′-PDE) catalyzes the hydrolysis of ribonucleic acid to obtain a mixture of ribonucleotides, such as 5′-guanosine monophosphate and 5′-adenosine monophosphate. In this … Continue reading

Research Article: The Unrecognized Effects of Phosphodiesterase 4 on Epithelial Cells in Pulmonary Inflammation

Date Published: April 24, 2015 Publisher: Public Library of Science Author(s): Franziska M. Konrad, Annette Bury, Martin A. Schick, Kristian-Christos Ngamsri, Jörg Reutershan, Xiao Su. http://doi.org/10.1371/journal.pone.0121725 Abstract: Acute pulmonary inflammation is characterized by migration of polymorphonuclear neutrophils (PMNs) into the different compartments of the lung, passing an endothelial and epithelial barrier. Recent studies showed evidence … Continue reading

Research Article: Identification and Characterization of a Novel Phosphodiesterase from the Metagenome of an Indian Coalbed

Date Published: February 6, 2015 Publisher: Public Library of Science Author(s): Durgesh Narain Singh, Ankush Gupta, Vijay Shankar Singh, Rajeev Mishra, Suneel Kateriya, Anil Kumar Tripathi, Shuang-yong Xu. http://doi.org/10.1371/journal.pone.0118075 Abstract: Phosphoesterases are involved in the degradation of organophosphorus compounds. Although phosphomonoesterases and phosphotriesterases have been studied in detail, studies on phosphodiesterases are rather limited. In … Continue reading

Research Article: Phosphodiesterase 5 Attenuates the Vasodilatory Response in Renovascular Hypertension

Date Published: November 15, 2013 Publisher: Public Library of Science Author(s): Johannes Stegbauer, Sebastian Friedrich, Sebastian A. Potthoff, Kathrin Broekmans, Miriam M. Cortese-Krott, Ivo Quack, Lars Christian Rump, Doris Koesling, Evanthia Mergia, Alexander Pfeifer. http://doi.org/10.1371/journal.pone.0080674 Abstract: NO/cGMP signaling plays an important role in vascular relaxation and regulation of blood pressure. The key enzyme in the … Continue reading

Research Article: Bacterial Cyclic AMP-Phosphodiesterase Activity Coordinates Biofilm Formation

Date Published: July 29, 2013 Publisher: Public Library of Science Author(s): Eric J. Kalivoda, Kimberly M. Brothers, Nicholas A. Stella, Matthew J. Schmitt, Robert M. Q. Shanks, Michael M. Meijler. http://doi.org/10.1371/journal.pone.0071267 Abstract: Biofilm-related infections are a major contributor to human disease, and the capacity for surface attachment and biofilm formation are key attributes for the … Continue reading

Research Article: Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling

Date Published: April 11, 2011 Publisher: Public Library of Science Author(s): Xia Tian, Christina Vroom, Hossein Ardeschir Ghofrani, Norbert Weissmann, Ewa Bieniek, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly, Soni Savai Pullamsetti, Wael El-Rifai. http://doi.org/10.1371/journal.pone.0018136 Abstract: Phosphodiesterases (PDEs) modulate the cellular proliferation involved in the pathophysiology of pulmonary hypertension (PH) by hydrolyzing cAMP and cGMP. The … Continue reading

Research Article: Combination phosphodiesterase type 4 inhibitor and phosphodiesterase type 5 inhibitor treatment reduces non-voiding contraction in a rat model of overactive bladder

Date Published: August 28, 2019 Publisher: Public Library of Science Author(s): Brian M. Balog, Abhilasha Tangada, Pooja Sheth, Qi-Xiang Song, Bruna M. Couri, Leah L. Porras, Gary G. Deng, Margot S. Damaser, Michael Bader. http://doi.org/10.1371/journal.pone.0220788 Abstract: Current treatments for overactive bladder (OAB) are often discontinued due to side effects or lack of efficacy. The goal … Continue reading

Research Article: The Selective Phosphodiesterase 4 Inhibitor Roflumilast and Phosphodiesterase 3/4 Inhibitor Pumafentrine Reduce Clinical Score and TNF Expression in Experimental Colitis in Mice

Date Published: February 28, 2013 Publisher: Public Library of Science Author(s): Florian Rieder, Britta Siegmund, Daniela S. Bundschuh, Hans-Anton Lehr, Stefan Endres, Andreas Eigler, Stefan Bereswill. http://doi.org/10.1371/journal.pone.0056867 Abstract: The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis. We examined the … Continue reading

Research Article: Cyclic AMP Control Measured in Two Compartments in HEK293 Cells: Phosphodiesterase KM Is More Important than Phosphodiesterase Localization

Date Published: September 8, 2011 Publisher: Public Library of Science Author(s): Karina Matthiesen, Jacob Nielsen, Karl-Wilhelm Koch. http://doi.org/10.1371/journal.pone.0024392 Abstract: The intracellular second messenger cyclic AMP (cAMP) is degraded by phosphodiesterases (PDE). The knowledge of individual families and subtypes of PDEs is considerable, but how the different PDEs collaborate in the cell to control a cAMP signal … Continue reading

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