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The molecular structure of a phospholipid is shown. It consists of two fatty acids attached to the first and second carbons in glycerol, and a phosphate group attached to the third position. The phosphate group may be further modified by addition of another molecule to one of its oxygens. Two molecules that may modify the phosphate group, choline and serine, are shown. Choline consists of a two-carbon chain with a hydroxy group attached to one end and a nitrogen attached to the other. The nitrogen, in turn, has three methyl groups attached to it and has a charge of plus one. Serine consists of a two-carbon chain with a hydroxyl group attached to one end. An amino group and a carboxyl group are attached to the other end.
A phospholipid is a molecule with two fatty acids and a modified phosphate group attached to a glycerol backbone. Adding a charged or polar chemical group may modify the phosphate.

Source: OpenStax Biology 2e

Phospholipids (OpenStax Biology 2e)

Phospholipids are major plasma membrane constituents that comprise cells’ outermost layer. Like fats, they are comprised of fatty acid chains attached to a glycerol or sphingosine backbone. However, instead of three fatty acids attached as in triglycerides, there are two fatty acids forming diacylglycerol, and a modified phosphate group occupies the glycerol backbone’s third carbon. A phosphate group alone attached to a diacylglycerol does not qualify as a phospholipid. It is phosphatidate (diacylglycerol 3-phosphate), the precursor of phospholipids. An alcohol modifies the phosphate group. Phosphatidylcholine and phosphatidylserine are two important phospholipids that are in plasma membranes.

– Phospholipids are the major components of what cell structure?

The first phospholipid identified in 1847 as such in biological tissues was lecithin, or phosphatidylcholine, in the egg yolk of chickens by the French chemist and pharmacist Theodore Nicolas Gobley.

A phospholipid is an amphipathic molecule, meaning it has a hydrophobic and a hydrophilic part. The fatty acid chains are hydrophobic and cannot interact with water; whereas, the phosphate-containing group is hydrophilic and interacts with water.

An illustration of a phospholipids bilayer is shown. The phospholipids bilayer consists of two layers of phospholipids. The hydrophobic tails of the phospholipids face one another while the hydrophilic head groups face outward.
The phospholipid bilayer is the major component of all cellular membranes. The hydrophilic head groups of the phospholipids face the aqueous solution. The hydrophobic tails are sequestered in the middle of the bilayer.

Source: OpenStax Biology 2e

The head is the hydrophilic part, and the tail contains the hydrophobic fatty acids. In a membrane, a bilayer of phospholipids forms the structure’s matrix, phospholipids’ fatty acid tails face inside, away from water; whereas, the phosphate group faces the outside, aqueous side.

Phospholipids are responsible for the plasma membrane’s dynamic nature. If a drop of phospholipids is placed in water, it spontaneously forms a structure that scientists call a micelle, where the hydrophilic phosphate heads face the outside and the fatty acids face the structure’s interior.

– Phospholipid synthesis occurs in the cytosolic side of what cell structure?

Phospholipids have been widely used to prepare liposomal, ethosomal and other nanoformulations of topical, oral and parenteral drugs for differing reasons like improved bio-availability, reduced toxicity and increased permeability across membranes.


Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at:


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