Research Article: 1-(2-Bromo­acet­yl)-3-methyl-2,6-diphenyl­piperidin-4-one

Date Published: June 01, 2010

Publisher: International Union of Crystallography

Author(s): G. Aridoss, S. Sundaramoorthy, D. Velmurugan, K. S. Park, Y. T. Jeong.


In the title compound, C20H20BrNO2, the piperidone ring adopts a boat conformation. The phenyl rings are oriented at dihedral angles of 97.8 (2) and 96.0 (1)° with respect to the best plane through the piperidine ring. The dihedral angle between the two phenyl rings is 49.7 (1)°. In the crystal, bifurcated C—H⋯O hydrogen bonds form a R21(7) ring motif, linking the mol­ecules into centrosymmetric dimers.

Partial Text

For the biological activity of functionalized piperidines, see: Richardo et al. (1979 ▶); Schneider (1996 ▶); Mukhtar & Wright (2005 ▶); Aridoss et al. (2007 ▶); Winkler & Holan (1989 ▶). For related structures see: Aridoss et al. (2009a ▶,b ▶). For ring conformational analysis, see: Cremer & Pople (1975 ▶); Nardelli (1983 ▶).




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