Research Article: 1-(2-Chloro­benz­yl)-3-methyl-2,6-diphenyl­piperidine

Date Published: July 01, 2012

Publisher: International Union of Crystallography

Author(s): Chennan Ramalingan, Seik Weng Ng, Edward R. T. Tiekink.


In the title compound, C25H26ClN, the piperidine ring has a chair conformation with all ring substituents in equatorial positions. The dihedral angle formed between the chloro­benzene ring and the flanking phenyl rings are 74.91 (18) and 47.86 (17)°. The chloro substituent is anti to the piperidine N atom. In the crystal, centrosymmetrically related mol­ecules aggregate via π–π inter­actions occurring between chloro­benzene rings [centroid–centroid distance = 3.778 (2) Å] and these are linked into linear supra­molecular chains along the a axis by C—H⋯π inter­actions occurring between the phenyl rings.

Partial Text

For the biological activity of piperidine derivatives, see: Ramalingan et al. (2004 ▶); Ramachandran et al. (2011 ▶). For a related structure, see: Ramalingan et al. (2012 ▶).




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