Research Article: 1-(2,4-Dichloro­phen­yl)-5-(2-nitro­anilino)-1H-pyrazole-4-carbonitrile

Date Published: April 01, 2012

Publisher: International Union of Crystallography

Author(s): Ju Liu, Zhi-Qiang Cai, Yang Wang, Chun-Yan Li, Li-Feng Xu.


In the title compound, C16H9Cl2N5O2, the folded mol­ecular conformation is characterized by a dihedral angle between the two benzene rings of 74.03 (5)°. An intra­molecular N—H⋯O hydrogen bond is observed between the H atom of the amide group and a nitro-group O atom. Inter­molecular C—H⋯O and N—H⋯N hydrogen bonds feature in the crystal packing.

Partial Text

For general background to N-1-diaryl-1H-pyrazol-5-amine derivatives as synthetic inter­mediates in the preparation of medicinal compounds and the synthesis of the title compound, see: Markwalder et al. (2004 ▶); Mehdi et al. (2010 ▶). For the pharmacological activity of the 5-amino­pyrazole nucleus, see: Nils et al. (2010 ▶); Aymn et al. (2005 ▶).