Date Published: April 01, 2012
Publisher: International Union of Crystallography
Author(s): Ju Liu, Zhi-Qiang Cai, Yang Wang, Chun-Yan Li, Li-Feng Xu.
In the title compound, C16H9Cl2N5O2, the folded molecular conformation is characterized by a dihedral angle between the two benzene rings of 74.03 (5)°. An intramolecular N—H⋯O hydrogen bond is observed between the H atom of the amide group and a nitro-group O atom. Intermolecular C—H⋯O and N—H⋯N hydrogen bonds feature in the crystal packing.
For general background to N-1-diaryl-1H-pyrazol-5-amine derivatives as synthetic intermediates in the preparation of medicinal compounds and the synthesis of the title compound, see: Markwalder et al. (2004 ▶); Mehdi et al. (2010 ▶). For the pharmacological activity of the 5-aminopyrazole nucleus, see: Nils et al. (2010 ▶); Aymn et al. (2005 ▶).