Research Article: 1-{4-[Bis(4-fluoro­phen­yl)meth­yl]piperazin-1-yl}ethanone

Date Published: July 01, 2012

Publisher: International Union of Crystallography

Author(s): A. S. Dayananda, H. S. Yathirajan, Amanda C. Keeley, Jerry P. Jasinski.

http://doi.org/10.1107/S1600536812028097

Abstract

In the title compound, C19H20F2N2O, the six-membered piperazine group adopts a slightly distorted chair conformation. The dihedral angle between the mean planes of the two benzene rings is 73.4 (6)°. The mean plane of the ethanone group is twisted from the mean planes of the two benzene rings by 66.7 (8) and 86.2 (6)°. In the crystal, C—H⋯O and C—H⋯F inter­actions link the molecules, forming a three-dimensional structure.

Partial Text

For the biological activity of piperazines, see: Bogatcheva et al. (2006 ▶); Brockunier et al. (2004 ▶). For a review of pharmacological and toxicological information for piperazine derivatives, see: Elliott (2011 ▶). For related structures, see: Betz et al. (2011a ▶,b ▶); Dai et al. (2012 ▶); Dayananda et al. (2012a ▶,b ▶); Zhong et al. (2011 ▶). For puckering parameters, see: Cremer & Pople (1975 ▶). For reference bond-length data, see Allen et al. (1987 ▶).

Source:

http://doi.org/10.1107/S1600536812028097