Date Published: May 01, 2010
Publisher: International Union of Crystallography
Author(s): Sohail Saeed, Naghmana Rashid, Wing-Tak Wong.
The title compound, C12H9ClN2OS2, exists in the thioamide form with an intramolecular N—H⋯O hydrogen bond across the thiourea and the carbonyl group. The dihedral angle between the rings is 10.36 (11)°. In the crystal structure, molecules are linked into chains by weak intermolecular C—H⋯Cl hydrogen-bonding interactions.
For general background to the biological activity of thiourea derivatives, see: Xu et al. (2004 ▶); Gu et al. (2007 ▶). For related structures, see: Saeed et al. (2008 ▶, 2009 ▶). For the cytotoxicity of anticancer drugs to normal cells in cancer therapy, see: Saeed et al. (2010 ▶).