Research Article: 1-(4-Chloro­phen­yl)-3-(2-thienylcarbon­yl)thio­urea

Date Published: May 01, 2010

Publisher: International Union of Crystallography

Author(s): Sohail Saeed, Naghmana Rashid, Wing-Tak Wong.

http://doi.org/10.1107/S1600536810013863

Abstract

The title compound, C12H9ClN2OS2, exists in the thio­amide form with an intra­molecular N—H⋯O hydrogen bond across the thio­urea and the carbonyl group. The dihedral angle between the rings is 10.36 (11)°. In the crystal structure, mol­ecules are linked into chains by weak inter­molecular C—H⋯Cl hydrogen-bonding inter­actions.

Partial Text

For general background to the biological activity of thio­urea derivatives, see: Xu et al. (2004 ▶); Gu et al. (2007 ▶). For related structures, see: Saeed et al. (2008 ▶, 2009 ▶). For the cytotoxicity of anti­cancer drugs to normal cells in cancer therapy, see: Saeed et al. (2010 ▶).

Source:

http://doi.org/10.1107/S1600536810013863