Research Article: 1-[5-(2-Chloro­phen­yl)-5-hy­droxy-3-methyl-4,5-dihydro-1H-pyrazol-1-yl]­ethanone

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Sheng-Hai Guo, Ji-Liang Wang, Dong-Qiang Guo, Xin-Ying Zhang.


The title compound, C12H13ClN2O2, crystallizes with two independent but very similar mol­ecules (A and B) in the asymmetric unit. The pyrazole ring in each mol­ecule has an envelope conformation. The dihedral angle between the pyrazole ring mean plane and the benzene ring is 86.07 (14)° in A and 85.99 (14)° in B. In the crystal, the A and B mol­ecules are linked via a pair of O—H⋯O hydrogen bonds, forming dimers. These dimers are further linked via C—H⋯O inter­actions to form –A–B–A–B– chains propagating along the c-axis direction.

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For the bioactivities of 5-hy­droxy­pyrazolines, see: Sauzem et al. (2008 ▶); Zhao et al. (2009 ▶); Idrees et al. (2009 ▶). For the crystal structures of related 5-hy­droxy­pyrazolines, see: Kargar, Kia, Froozandeh et al. (2011 ▶); Kargar, Kia, Moghadamm et al. (2011 ▶).