Research Article: 1-(5-Bromo-2-oxoindolin-3-yl­idene)thio­semicarbazide acetonitrile monosolvate

Date Published: July 01, 2011

Publisher: International Union of Crystallography

Author(s): Fernanda Rosi Soares Pederzolli, Leandro Bresolin, Vanessa Santana Carratu, Aline Locatelli, Adriano Bof de Oliveira.


In the crystal structure of the title compound, C9H7BrN4OS·C2H3N, the mol­ecules are connected via N—H⋯O and N—H⋯S inter­actions into zigzag chains perpendicular to [001]. The mol­ecules in these chains are additionally linked to acetonitrile solvent mol­ecules through N—H⋯N hydrogen bonding. The mol­ecules are arranged in layers and are stacked in the direction of the c axis indicative of π–π inter­actions, with distance = 3.381 (7) Å for the C⋯C interaction parallel to [001]. An intra­molecular N—H⋯O hydrogen bond is also observed in the main mol­ecule.

Partial Text

For the pharmacological properties of isatin-thio­semicarbazone derivatives against cruzain, falcipain-2 and rhodesain, see: Chiyanzu et al. (2003 ▶). For the synthesis of 5-bromo­isatin-3-thio­semicarbazone, see: Campaigne & Archer (1952 ▶).




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