Research Article: 1-(Adamantan-1-yl)-3-(4-fluoro­phen­yl)thio­urea

Date Published: May 01, 2012

Publisher: International Union of Crystallography

Author(s): Güneş Demirtaş, Necmi Dege, Mona M. Al-Shehri, Ali A. El-Emam, Nasser R. El-Brollosy, Orhan Büyükgüngör.


In the title mol­ecule, C17H21FN2S, the mean planes of the benzene ring and the thio­urea fragment form a dihedral angle of 61.93 (9)°. In the crystal, pairs of weak N—H⋯S inter­actions link the mol­ecules, forming inversion dimers.

Partial Text

For background to the biological activity of adamantane and thio­urea derivatives, see: Vernier et al. (1969 ▶); El-Emam et al. (2004 ▶); Li et al. (2009 ▶); Hunter et al. (2008 ▶); Kadi et al. (2007 ▶, 2010 ▶). For the crystal structures of related adamantane deriv­atives, see: Kadi et al. (2011 ▶); Almutairi et al. (2012 ▶); Al-Abdullah et al. (2012 ▶).