Research Article: 1-(Biphenyl-4-ylmethyl­idene)thio­semicarbazide monohydrate

Date Published: May 01, 2010

Publisher: International Union of Crystallography

Author(s): Rafael Mendoza-Meroño, Laura Menéndez-Taboada, Eva Fernández-Zapico, Santiago García-Granda.


In the title compound, C14H13N3S·H2O, the thio­semicarbazide group is nearly planar, with a maximum deviation of 0.072 (2) Å from the ideal least-squares plane, and shows an E conformation. In the crystal packing, the water mol­ecules are involved in an extensive inter­molecular N—H⋯O hydrogen-bond network, assisted by O—H⋯S inter­actions, which link the independent mol­ecules into chains extended along b axis. An intra­molecular hydrogen N—H⋯N bond helps to stabilize the mol­ecular conformation.

Partial Text

For the biological activity and potential medical applications of thio­semicarbazides, see: West et al. (1991 ▶). For thio­semicarbazides as ligands, see: Kowol et al. (2007 ▶).




0 0 vote
Article Rating
Notify of
Inline Feedbacks
View all comments