Research Article: 1-Dichloro­acetyl-8a-methyl-1,2,3,4,6,7,8,8a-octa­hydro­pyrrolo­[1,2-a]pyrimidin-6-one

Date Published: July 01, 2012

Publisher: International Union of Crystallography

Author(s): Shuang Gao, Li-xia Zhao, Fei Ye, Ying Fu, Zhi-yong Xing.

http://doi.org/10.1107/S1600536812024063

Abstract

In the title compound, C10H14Cl2N2O2, the five-membered ring adopts an envelope conformation (with the methylene C atom closest to the C—N bridge as the flap), while the conformation of the six-membered ring is close to a twist-boat. In the crystal, mol­ecules are linked by weak C—H⋯O hydrogen bonds, forming chains along the c-axis direction.

Partial Text

For general background to 1,5-diaza­bicyclo compounds, see: Fuerst & Lamoureux (1992 ▶); Hutton & Bartlett (2007 ▶); Koptelov et al. (2011 ▶); Loriga et al. (2007 ▶); Moreland et al. (1993 ▶); Taylor et al. (2010 ▶). For details of the synthesis, see: Sun & Ye (2010 ▶); Rohr et al. (1984 ▶,1986 ▶). For applications of N-dichloro­acetyl-1,5-diaza­bicyclo compounds, see: Lamour­eux & Rusness (1992 ▶); Hatzios & Burgos (2004 ▶).

Source:

http://doi.org/10.1107/S1600536812024063