Research Article: 1,2-Bis[(3,6,9-trimethyl-3,12-ep­oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca­hydro­pyrano[4,3-j][1,2]benzodioxepin-4-yl)­oxy]ethane

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Liwei Jia, Zhengyu Yue, Dongying Lv, Po Gao.


The title compound, C32H50O10, prepared from a mixture of α- and β-dihydro­artemisinin, has two β-arteether moieties linked via an –OCH2CH2O– bridge, so that the mol­ecule is symmetric about the bridge. Each asymmetric unit contains a β-arteether moiety and an –OCH2 group, which is only one-half of the mol­ecule. The endo-peroxide bridges of the parent compounds have been retained in each half of the diol-bridged dimer. The rings exhibit chair and twist-boat conformations.

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For related literature and structures, see: Brossi et al. (1988 ▶); Dominguez Gerpe et al. (1988 ▶); Flack & Bernardinelli (2000 ▶); Flippen-Anderson et al. (1989 ▶); Haynes et al. (2002 ▶); Luo et al. (1984 ▶); Paik et al. (2006 ▶); Qinghaosu Research Group (1980 ▶); Venugopalan et al. (1995 ▶); Woerdenbag et al. (1993 ▶); Yue et al. (2006 ▶). For the synthesis, see: Posner et al. (1997 ▶). For puckering parameters, see: Cremer & Pople (1975 ▶).