Research Article: (1S,3R)-3-Isobutyl-2,3-dihydro­spiro[benzo[f]isoindole-1,3′-indoline]-2′,4,9-trione methanol monosolvate

Date Published: August 01, 2012

Publisher: International Union of Crystallography

Author(s): Garima Sharma, S. Vasanth Kumar, Habibah A. Wahab, Mohd Mustaqim Rosli, Hoong-Kun Fun.


In the title compound, C23H20N2O3·CH3OH, the hexa­hydro-1H-benzo[f]isoindole and indoline rings are planar, with maximum deviations of 0.092 (1) and −0.095 (1) Å, respectively. The dihedral angle between these two rings is 88.03 (4)°. An O—H⋯N inter­action links the main mol­ecule and the methanol solvent mol­ecule. An intra­molecular C—H⋯O inter­action forms an S(6) ring motif. In the crystal, the mol­ecules form two-dimensional layers parallel to the bc plane through N—H⋯O and C—H⋯O inter­actions.

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For biological activities of naphtho­quinones, see: Babula et al. (2007 ▶). For detailed literature on naphtho­quinone chemistry, see: Chen et al. (2011 ▶); Silva et al. (2002 ▶). For hydrogen-bond motifs, see: Bernstein et al. (1995 ▶). For the stability of the temperature controller used for the data collection, see: Cosier & Glazer (1986 ▶).




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