Research Article: 2-(2-Fluoro-4-hy­droxy­benz­yl)isoindoline-1,3-dione

Date Published: August 01, 2012

Publisher: International Union of Crystallography

Author(s): Hilal Vesek, Canan Kazak, Ayşen Alaman Ağar, Sümeyye Gümüş, Muhittin Aygün.


In the title compound, C15H10FNO3, the dihedral angle between the isoindoline-1,3-dione and 3-fluoro-4-methyl­phenol groups is 86.88 (8)°. The isoindoline-1,3-dione fragment is almost planar, with an r.m.s. deviation of 0.0154 Å within the group. Inter­molecular C—H⋯O hydrogen bonds generate C(6) chains running parallel to the [010] direction.

Partial Text

For background to indoline-1,3-dione and its derivatives, see: Raza et al. (2010 ▶). For discussion of the broad spectrum of properties of these compounds, see: Bhattacharya & Chakrabarti (1998 ▶). For discussion of their anti-inflammatory properties, see: Sridhar & Ramesh (2001 ▶). For discussion of their anxiogenic activities, see: Medvedev et al. (1996 ▶). For related structures, see: Asad et al. (2012 ▶); Fu et al. (2010 ▶). For classification of hydrogen-bonding patterns, see: Bernstein et al. (1995 ▶).




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