Research Article: 2-(2-Iodo­phen­yl)-1,2,3,4-tetra­hydro­isoquinoline-1-carbonitrile

Date Published: June 01, 2011

Publisher: International Union of Crystallography

Author(s): Yanni Ma, Yifang Sun, Feng Zheng, Wenwen Sun, Le Zhou.


In the title compound, C16H13IN2, the two benzene rings make a dihedral angle of 67.26 (5)°. The six-membered heterocycle of the tetra­hydro­isoquinoline unit adopts a half-chair conformation. In the crystal, adjacent mol­ecules are linked by pairs of weak inter­molecular C—H⋯N hydrogen bonds, forming inversion dimers. An intra­molecular C—H⋯I close contact is also observed.

Partial Text

For the synthesis of the title compound, see: Ishii et al. (1985 ▶). For the biological activity of tetra­hydro­isoquinoline derivatives, see: Abe et al. (2005 ▶); Kamal et al. (2011 ▶); Lane et al. (2006 ▶); Liu et al. (2009 ▶); Storch et al. (2002 ▶); Wright et al. (1990 ▶).




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