Date Published: May 01, 2012
Publisher: International Union of Crystallography
Author(s): Nazia Sattar, Hamid Latif Siddiqui, Matloob Ahmad, Muhammad Akram, Masood Parvez.
In the title molecule, C22H15Cl2NO4S, the heterocyclic thiazine ring adopts a half-chair conformation, with the S and N atoms displaced by 0.343 (5) and 0.402 (5) Å, respectively, on opposite sides of the mean plane formed by the remaining ring atoms. The molecular structure is consolidated by an intramolecular O—H⋯O hydrogen bond, which generates an S(?) ring. In the crystal, the molecules are linked by C—H⋯O interactions into  chains.
For background information on the activity of anti-inflammatory and analgesic oxicams, see: Lombardino et al. (1971 ▶); Soler (1985 ▶); Carty et al. (1993 ▶); Turck et al. (1995 ▶); Blackham & Owen (1975 ▶). For the biological activity of benzothiazine derivatives, see: Zia-ur-Rehman et al. (2005 ▶); Ahmad et al. (2010 ▶). For the syntheses and crystal stuctures of related benzothiazine derivatives, see: Ahmad et al. (2011 ▶); Aslam et al. (2012 ▶).