Research Article: 2-(2,5-Dimeth­oxy­phen­yl)-N-[2-(4-hy­droxy­phen­yl)eth­yl]acetamide

Date Published: April 01, 2012

Publisher: International Union of Crystallography

Author(s): Hyeong Choi, Yong Suk Shim, Byung Hee Han, Sung Kwon Kang, Chang Keun Sung.


In the title compound, C18H21NO4, the dihedral angles between the acetamide group and the meth­oxy- and hy­droxy-substitured benzene rings are 80.81 (5) and 8.19 (12)°, respectively. The benzene rings are twisted with respect to each other, making a dihedral angle of 72.89 (5)°. In the crystal, N—H⋯O and O—H⋯O hydrogen bonds link the mol­ecules into a three-dimensional network.

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For general background to tyrosinase, see: Kubo et al. (2000 ▶). For the development of tyrosinase inhibitors, see: Lemic-Stojcevic et al. (1995 ▶); Battaini et al. (2000 ▶); Cabanes et al. (1994 ▶); Thanigaimalai et al. (2010 ▶).