Date Published: May 01, 2009
Publisher: International Union of Crystallography
Author(s): Quan Qin, Li Juan Xu, Li Fang Pan, Shui Qing Chen, Qing Bao Song.
In the title compound, C18H15ClFN3O4, the dihedral angle between the substituted pyridine ring and the oxadiazoline ring is 9.73 (19)° and the acyl group is coplanar with the oxadiazoline ring [O—C—N—C torsion angle = −2.1 (3)°]. Furthermore, the substituted benzene ring is almost orthogonal with the oxadiazoline ring, the dihedral angle between them being 87.56 (18)°.
For background to 1,3,4-oxadiazoline derivatives and related structures, see: Song et al. (2006a ▶,b ▶); Pan et al. (2007 ▶). For the pharmacological properties of 2,5-disubstituted 1,3,4-oxadiazolines, see: Chimirri et al. (1994 ▶, 1996 ▶); Dogan et al. (1998 ▶).