Research Article: 2-[3-Acetyl-5-(2-chloro-3-pyrid­yl)-2-methyl-2,3-dihydro-1,3,4-oxadiazol-2-yl]-4-fluoro­phenyl acetate

Date Published: May 01, 2009

Publisher: International Union of Crystallography

Author(s): Quan Qin, Li Juan Xu, Li Fang Pan, Shui Qing Chen, Qing Bao Song.


In the title compound, C18H15ClFN3O4, the dihedral angle between the substituted pyridine ring and the oxadiazo­line ring is 9.73 (19)° and the acyl group is coplanar with the oxadiazo­line ring [O—C—N—C torsion angle = −2.1 (3)°]. Furthermore, the substituted benzene ring is almost orthogonal with the oxadiazo­line ring, the dihedral angle between them being 87.56 (18)°.

Partial Text

For background to 1,3,4-oxadiazo­line derivatives and related structures, see: Song et al. (2006a ▶,b ▶); Pan et al. (2007 ▶). For the pharmacological properties of 2,5-disubstituted 1,3,4-oxa­diazo­lines, see: Chimirri et al. (1994 ▶, 1996 ▶); Dogan et al. (1998 ▶).




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