Research Article: 2-[(4-Chloro­benz­yl)sulfan­yl]-4-(2-methyl­prop­yl)-6-(phenyl­sulfan­yl)pyrimidine-5-carbonitrile

Date Published: July 01, 2012

Publisher: International Union of Crystallography

Author(s): Ali A. El-Emam, Omar A. Al-Deeb, Abdulghafoor A. Al-Turkistani, Seik Weng Ng, Edward R. T. Tiekink.


In the title compound, C22H20ClN3S2, the S-bound benzene rings are inclined [dihedral angles = 78.13 (10) and 36.70 (9)°] with respect to the pyrimidine ring. The methyl­propyl group occupies a position normal to the pyrimidine ring [N—C—C—C torsion angle = 92.3 (2)°]. In the crystal, supra­molecular layers are formed in the bc plane, being consolidated by C—H⋯π and π—π inter­actions, the latter between the pyrimidine and S-bound benzene rings [inter-centroid distance = 3.7683 (12) Å].

Partial Text

For the chemotherapeutic activity of pyrimidine derivatives, see: Al-Abdullah et al. (2011 ▶); Brunelle et al. (2007 ▶); Ding et al. (2006 ▶); Al-Safarjalani et al. (2005 ▶). For a related pyrimidine structure, see: El-Emam et al. (2011 ▶).




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