Research Article: 2-Amino-3,4,5,6-tetra­fluoro­benzoic acid

Date Published: July 01, 2011

Publisher: International Union of Crystallography

Author(s): Xiao-Jian Liao, Wei Guo, Shi-Hai Xu.


The asymmetric unit of the title compound, C7H3F4NO2, obtained as an inter­mediate in the synthesis of a coupling reagent, contains four independent and conformationally similar mol­ecules. The amine H atoms form both intra­molecular and inter­molecular N—H⋯Ocarbox­yl hydrogen bonds which, together with inter­molecular O—H⋯Ocarbox­yl hydrogen bonds and N—H⋯F associations form ribbon structures along the a axis.

Partial Text

The title compound was obtained as one of the inter­mediates in the synthesis of a coupling reagent (Xu et al., 2008 ▶; Liao et al., 2007 ▶), using the Hofmann rearrangement (Perumal & Muthialu, 2004 ▶) with 2-carboxyl-3,4,5,6-tetra­fluoro­benzamide (Cai et al., 1992 ▶).




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