Date Published: July 01, 2011
Publisher: International Union of Crystallography
Author(s): Xiao-Jian Liao, Wei Guo, Shi-Hai Xu.
The asymmetric unit of the title compound, C7H3F4NO2, obtained as an intermediate in the synthesis of a coupling reagent, contains four independent and conformationally similar molecules. The amine H atoms form both intramolecular and intermolecular N—H⋯Ocarboxyl hydrogen bonds which, together with intermolecular O—H⋯Ocarboxyl hydrogen bonds and N—H⋯F associations form ribbon structures along the a axis.
The title compound was obtained as one of the intermediates in the synthesis of a coupling reagent (Xu et al., 2008 ▶; Liao et al., 2007 ▶), using the Hofmann rearrangement (Perumal & Muthialu, 2004 ▶) with 2-carboxyl-3,4,5,6-tetrafluorobenzamide (Cai et al., 1992 ▶).