Date Published: March 01, 2012
Publisher: International Union of Crystallography
Author(s): Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Seik Weng Ng, Edward R. T. Tiekink.
The title molecule, C22H17BrN2O4S, has a twisted U shape, the dihedral angle between the quinazolin-4-one and bromobenzene ring systems being 46.25 (8)°. In order to avoid steric clashes with adjacent substituents on the quinazolin-4-one ring, the N-bound tolyl group occupies an orthogonal position [dihedral angle = 89.59 (8)°]. In the crystal, molecules are connected into a three-dimensional architecture by C—H⋯O interactions, with the ketone O atom accepting two such bonds and a sulfonate O atom one.
For the pharmacological activity of substituted quinazoline-4(3H)-ones, see: El-Azab & El-Tahir (2012 ▶); El-Azab et al. (2011 ▶); Al-Omary et al. (2010 ▶); Al-Obaid et al. (2009 ▶); Aziza et al. (1996 ▶). For the synthesis and evaluation of the anti-convulsant activity of the title compound, see: El-Azab et al. (2010 ▶).