Date Published: July 01, 2012
Publisher: International Union of Crystallography
Author(s): Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Amer M. Alanazi, Seik Weng Ng, Edward R. T. Tiekink.
In the title compound, C23H17ClN2O3, the quinazoline fused-ring system, including the ring-bound carbonyl-O and methyl-C atoms, is close to being planar (r.m.s. deviation = 0.044 Å) and is essentially orthogonal to both the 2-tolyl ring [dihedral angle = 89.51 (8)°] and to the ester group [the C—O—C—C torsion angle = −103.69 (16)°]. The carboxylate group is almost coplanar with the benzene ring to which it is attached [O—C—C—C torsion angle = −4.7 (2)°]. The 2-tolyl ring system is disordered over two orientations in a 0.871 (3):0.129 (3) ratio. In the crystal, molecules are consolidated into a three-dimensional architecture by C—H⋯Cl, C—H⋯O, C—H⋯N, C—H⋯π and π–π interactions [inter-centroid distances = 3.6443 (9) and 3.8557 (11) Å].
For further synthetic details and the anti-convulsant activity of the title compound, see: El-Azab et al. (2011 ▶).