Research Article: 2-Methyl-3-(2-methyl­phen­yl)-4-oxo-3,4-dihydro­quinazolin-8-yl 4-chloro­benzoate

Date Published: July 01, 2012

Publisher: International Union of Crystallography

Author(s): Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Amer M. Alanazi, Seik Weng Ng, Edward R. T. Tiekink.

http://doi.org/10.1107/S1600536812025147

Abstract

In the title compound, C23H17ClN2O3, the quinazoline fused-ring system, including the ring-bound carbonyl-O and methyl-C atoms, is close to being planar (r.m.s. deviation = 0.044 Å) and is essentially orthogonal to both the 2-tolyl ring [dihedral angle = 89.51 (8)°] and to the ester group [the C—O—C—C torsion angle = −103.69 (16)°]. The carboxyl­ate group is almost coplanar with the benzene ring to which it is attached [O—C—C—C torsion angle = −4.7 (2)°]. The 2-tolyl ring system is disordered over two orientations in a 0.871 (3):0.129 (3) ratio. In the crystal, mol­ecules are consolidated into a three-dimensional architecture by C—H⋯Cl, C—H⋯O, C—H⋯N, C—H⋯π and π–π inter­actions [inter-centroid distances = 3.6443 (9) and 3.8557 (11) Å].

Partial Text

For further synthetic details and the anti-convulsant activity of the title compound, see: El-Azab et al. (2011 ▶).

Source:

http://doi.org/10.1107/S1600536812025147