Date Published: March 01, 2012
Publisher: International Union of Crystallography
Author(s): Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Seik Weng Ng, Edward R. T. Tiekink.
In the title quinazolin-4-one derivative, C24H20N2O3, both the 4-methylbenzoate [dihedral angle = 83.90 (9)°] and 2-tolyl [87.88 (9)°] groups are almost orthogonal to the central fused ring system. These aryl groups are oriented towards the quinazolin-4-one-bound methyl group. In the crystal, molecules are connected into a three-dimensional architecture by C—H⋯O, C—H⋯π and π–π [ring centroid-to-centroid separation = 3.6458 (13) Å] interactions.
For the pharmacological activity of substituted quinazoline-4(3H)-ones, see: El-Azab & ElTahir (2012 ▶); El-Azab et al. (2011 ▶); Al-Omary et al. (2010 ▶); Al-Obaid et al. (2009 ▶); Aziza et al. (1996 ▶). For the synthesis and evaluation of the anticonvulsant activity of the title compound, see: El-Azab et al. (2010 ▶). For the structure of the benzoate derivative, see: El-Azab et al. (2012 ▶).