Research Article: 2-Methyl-3-(2-methyl­phen­yl)-4-oxo-3,4-dihydro­quinazolin-8-yl thio­phene-2-carboxyl­ate

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Seik Weng Ng, Edward R. T. Tiekink.

http://doi.org/10.1107/S1600536812006459

Abstract

In the title compound, C21H16N2O3S, the central quinazolin-4-one ring is planar (r.m.s. deviation = 0.037 Å). The N-bound benzene and thio­phenyl rings are almost perpendicular to the central plane [dihedral angles = 82.22 (5) and 77.05 (13)°, respectively]. Mol­ecules are connected into a three-dimensional array by C—H⋯O inter­actions involving both carbonyl O atoms. The thio­phene ring is disordered over two positions, which are approximately parallel and oppositely orientated. The major component refined to a site-occupancy factor of 0.6555 (17).

Partial Text

For the pharmacological activity of substituted quinazolin-4(3H)-ones, see: El-Azab & El-Tahir (2012 ▶); El-Azab et al. (2010 ▶, 2011 ▶); Al-Omary et al. (2010 ▶); Al-Obaid et al. (2009 ▶); Aziza et al. (1996 ▶). For the synthesis and evaluation of the anti-convulsant activity of the title compound, see: El-Azab et al. (2010 ▶).

 

Source:

http://doi.org/10.1107/S1600536812006459