Research Article: 2-Methyl-3-(2-methyl­phen­yl)-7-nitro­quinazolin-4(3H)-one

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Seik Weng Ng, Edward R. T. Tiekink.


In the title methaqua­lone analogue, C16H13N3O3, the 2-tolyl group is almost orthogonal [dihedral angle = 85.20 (5)°] to the fused ring system (r.m.s. deviation of fitted non-H atoms = 0.029 Å). In the crystal, twofold symmetry generates two-mol­ecule aggregates linked by C—H⋯O and π–π inter­actions [ring centroid–centroid distance = 3.4967 (6) Å].

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For recent studies on synthesis, drug discovery and crystal structures of quinazoline-4(3H)-one derivatives, see: El-Azab et al. (2010 ▶, 2012 ▶). For the anti-convulsant activity of the title methaqua­lone analogue, see: El-Azab et al. (2011 ▶). For a related structure, see: Stephenson et al. (2011 ▶).