Date Published: March 01, 2012
Publisher: International Union of Crystallography
Author(s): Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Seik Weng Ng, Edward R. T. Tiekink.
In the title methaqualone analogue, C16H13N3O3, the 2-tolyl group is almost orthogonal [dihedral angle = 85.20 (5)°] to the fused ring system (r.m.s. deviation of fitted non-H atoms = 0.029 Å). In the crystal, twofold symmetry generates two-molecule aggregates linked by C—H⋯O and π–π interactions [ring centroid–centroid distance = 3.4967 (6) Å].
For recent studies on synthesis, drug discovery and crystal structures of quinazoline-4(3H)-one derivatives, see: El-Azab et al. (2010 ▶, 2012 ▶). For the anti-convulsant activity of the title methaqualone analogue, see: El-Azab et al. (2011 ▶). For a related structure, see: Stephenson et al. (2011 ▶).