Research Article: 2-(N-Phenyl­methane­sulfonamido)­ethyl 1H-pyrrole-2-carboxyl­ate

Date Published: May 01, 2011

Publisher: International Union of Crystallography

Author(s): Salman Tariq Khan, Peng Yu, Aisha Nelofar, Zaheer Ahmed, Suchada Chantrapromma.


In the title compound, C14H16N2O4S, the eth­oxy­carbonyl group is nearly planar, with an r.m.s. deviation of 0.0067 Å, and is almost coplanar with the pyrrole ring [dihedral angle = 5.81 (15)°], whereas it is inclined at a dihedral angle of 61.90 (13)° to the phenyl ring. The dihedral angle between the pyrrole and phenyl rings is 56.15 (13)°. In the crystal, centrosymmetrically related mol­ecules are linked into dimers by pairs of N—H⋯O hydrogen bonds, forming rings of R22(10) graph-set motif. The dimers are further connected by weak inter­molecular C—H⋯O hydrogen bonds and C—H⋯π inter­actions, forming layers parallel to the bc plane.

Partial Text

For the pharmacological and biological activity of pyrrole-2-carboxyl­ate derivatives and sulfonamides, see: Brienne et al. (1987 ▶); Burnham et al. (1998 ▶); Fan et al. (2008 ▶); Fu et al. (2002 ▶); Gupton et al. (1999 ▶); Manzanaro et al. (2006 ▶); Mayer et al. (2009 ▶); Yoshikawa et al. (1993 ▶, 1998 ▶). For a related structure, see: Khan et al. (2010 ▶). For standard bond-length data, see: Allen et al. (1987 ▶).




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