Date Published: May 01, 2011
Publisher: International Union of Crystallography
Author(s): Salman Tariq Khan, Peng Yu, Aisha Nelofar, Zaheer Ahmed, Suchada Chantrapromma.
In the title compound, C14H16N2O4S, the ethoxycarbonyl group is nearly planar, with an r.m.s. deviation of 0.0067 Å, and is almost coplanar with the pyrrole ring [dihedral angle = 5.81 (15)°], whereas it is inclined at a dihedral angle of 61.90 (13)° to the phenyl ring. The dihedral angle between the pyrrole and phenyl rings is 56.15 (13)°. In the crystal, centrosymmetrically related molecules are linked into dimers by pairs of N—H⋯O hydrogen bonds, forming rings of R22(10) graph-set motif. The dimers are further connected by weak intermolecular C—H⋯O hydrogen bonds and C—H⋯π interactions, forming layers parallel to the bc plane.
For the pharmacological and biological activity of pyrrole-2-carboxylate derivatives and sulfonamides, see: Brienne et al. (1987 ▶); Burnham et al. (1998 ▶); Fan et al. (2008 ▶); Fu et al. (2002 ▶); Gupton et al. (1999 ▶); Manzanaro et al. (2006 ▶); Mayer et al. (2009 ▶); Yoshikawa et al. (1993 ▶, 1998 ▶). For a related structure, see: Khan et al. (2010 ▶). For standard bond-length data, see: Allen et al. (1987 ▶).