Research Article: 2,2-Diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate

Date Published: August 01, 2012

Publisher: International Union of Crystallography

Author(s): Long He.

http://doi.org/10.1107/S1600536812029625

Abstract

The title compound, C21H24N2O8, was synthesized by a 1,3-dipolar cyclo­addition reaction of dimethyl fumarate, diethyl 2-amino­malonate and 4-cyano­benzaldehyde. Both methyl ester groups display a trans configuration and the pyrrolidine ring possesses an envelope conformation, with the C atom in the 3-position as the flap. In the crystal, N—H⋯N hydrogen bonds and weak C—H⋯O inter­actions occur.

Partial Text

For the biological activity of pyrrolidine derivatives, see: Coldham & Hufton (2005 ▶); Pandey et al. (2006 ▶); Schreiber et al. (2000 ▶). For a related structure, see: He et al. (2010 ▶).

 

Source:

http://doi.org/10.1107/S1600536812029625

 

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