Date Published: August 01, 2012
Publisher: International Union of Crystallography
Author(s): Long He.
The title compound, C21H24N2O8, was synthesized by a 1,3-dipolar cycloaddition reaction of dimethyl fumarate, diethyl 2-aminomalonate and 4-cyanobenzaldehyde. Both methyl ester groups display a trans configuration and the pyrrolidine ring possesses an envelope conformation, with the C atom in the 3-position as the flap. In the crystal, N—H⋯N hydrogen bonds and weak C—H⋯O interactions occur.
For the biological activity of pyrrolidine derivatives, see: Coldham & Hufton (2005 ▶); Pandey et al. (2006 ▶); Schreiber et al. (2000 ▶). For a related structure, see: He et al. (2010 ▶).