Research Article: 2,4-Dichloro-7-fluoro­quinazoline

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Feng Gao, Yun-Fei Hu, Jin-Long Wang.


The mol­ecule of the title compound, C8H3Cl2FN2, is essentially planar, with a maximum deviation of 0.018 (2) Å. In the crystal, π–π stacking is observed between parallel quinazoline moieties of adjacent mol­ecules, the centroid–centroid distance being 3.8476 (14) Å.

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For the synthesis of quinazoline derivatives, see: Roberts et al. (2011 ▶); Gao et al. (2010 ▶); Li et al. (2009 ▶); Connolly et al. (2005 ▶). For the pharmacological properties of quinazoline analogues, see: Koller et al. (2011 ▶); Garofalo et al. (2011 ▶); Yang et al. (2011 ▶). For related structures, see: Jia et al. (2011 ▶); Ouahrouch et al. (2011 ▶).