Research Article: 2,6-Bis(4-chloro­phen­yl)-1,3-dimethyl­piperidin-4-one O-benzyl­oxime

Date Published: February 01, 2012

Publisher: International Union of Crystallography

Author(s): Dong Ho Park, V. Ramkumar, P. Parthiban.


The piperidin-4-one ring in the title compound, C26H26Cl2N2O, exists in a chair conformation with equatorial orientations of the methyl and 4-chlorophenyl groups. The C atom bonded to the oxime group is statistically planar (bond-angle sum = 360.0°) although the C—C=N bond angles are very different [117.83 (15) and 127.59 (15)°]. The dihedral angle between the chloro­phenyl rings is 54.75 (4)°. In the crystal, mol­ecules inter­act via van der Waals forces.

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For the synthesis and biological activity of piperidin-4-one derivatives, see: Parthiban et al. (2008 ▶). For related structures see: Parthiban et al. (2009a ▶,b ▶). For ring puckering parameters, see: Cremer & Pople (1975 ▶); Nardelli (1983 ▶).