Research Article: 2,6-Bis(4-meth­oxy­phen­yl)-1,3-dimethyl­piperidin-4-one O-benzyl­oxime

Date Published: February 01, 2012

Publisher: International Union of Crystallography

Author(s): Dong Ho Park, V. Ramkumar, P. Parthiban.


The central ring of the title compound, C28H32N2O3, exists in a chair conformation with an equatorial disposition of all the alkyl and aryl groups on the heterocycle. The para-anisyl groups on both sides of the secondary amino group are oriented at an angle of 54.75 (4)° with respect to each other. The oxime derivative exists as an E isomer with the methyl substitution on one of the active methyl­ene centers of the mol­ecule. The crystal packing features weak C—H⋯O inter­actions.

Partial Text

For the synthesis and biological activity of piperidin-4-ones, see: Parthiban et al. (2005 ▶, 2008 ▶, 2009a ▶, 2011 ▶). For related structures, see: Parthiban et al. (2009a ▶,b ▶); For ring puckering parameters, see: Cremer & Pople (1975 ▶); Nardelli (1983 ▶).