Date Published: April 01, 2011
Publisher: International Union of Crystallography
Author(s): Jerry P. Jasinski, Ray J. Butcher, H. S. Yathirajan, B.K. Sarojini, V. Musthafa Khaleel.
In the title compound, C15H11ClO2, the dihedral angle between the mean planes of the chlorobenzene and hydroxybenzene rings is 6.5 (6)°. The mean plane of the prop-2-en-1-one group makes an angle of 18.0 (1)° with the hydroxyphenyl ring and 11.5 (1)° with the chlorophenyl ring. The crystal packing is stabilized by intermolecular O—H⋯O hydrogen bonds, weak C—H⋯O, C—H⋯π and π–π stacking interactions [centroid–centroid distances = 3.7771 (7) and 3.6917 (7) Å].
For the biological properties of chalcones, see: Nowakowska (2007 ▶) and for their role in tubulin polymerization inhibition, see: Edwards et al. (1989 ▶). For related structures, see: Jasinski et al. (2010 ▶, 2011a ▶,b ▶); Butcher et al. (2007a ▶,b ▶); Narayana et al. (2007 ▶); Sarojini et al. (2007a ▶,b ▶). For standard bond lengths, see: Allen et al., (1987 ▶).