Research Article: (2R,6S)-tert-Butyl 2-(benzhydryl­carbamo­yl)-6-methyl­morpholine-4-carboxyl­ate

Date Published: June 01, 2011

Publisher: International Union of Crystallography

Author(s): Haiyang Wang, Guangxin Xia, Xuejun Liu, Jingkang Shen.


The title compound, C24H30N2O4, was obtained by the reaction of (2R,6S)-4-(tert-but­oxy­carbon­yl)-6-methyl­morpho­line-2-carb­oxy­lic acid with diphenyl­methanamine in dimethyl­formamide solution. The morpholine ring is in a chair conformation. In the crystal, weak inter­molecular C—H⋯O hydrogen bonds link mol­ecules into chains along the b axis.

Partial Text

For a review of the biological relevance and synthesis of C-substituted morpholine derivatives, see: Wijtmans et al. (2004 ▶). For applications of morpholine derivatives as drugs, see: Dando & Perry (2004 ▶); Hajos et al. (2004 ▶); Hale et al. (1998 ▶); Versiani et al. (2002 ▶). For agrochemical fungicides and bactericides containing a morpholine skeleton, see: Dieckmann et al. (1993 ▶). For applications of morpholines as chiral auxiliaries in asymmetric synthesis, see: Dave & Sasaki (2004 ▶); Enders et al. (1994 ▶).




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