Date Published: June 01, 2011
Publisher: International Union of Crystallography
Author(s): Haiyang Wang, Guangxin Xia, Xuejun Liu, Jingkang Shen.
The title compound, C24H30N2O4, was obtained by the reaction of (2R,6S)-4-(tert-butoxycarbonyl)-6-methylmorpholine-2-carboxylic acid with diphenylmethanamine in dimethylformamide solution. The morpholine ring is in a chair conformation. In the crystal, weak intermolecular C—H⋯O hydrogen bonds link molecules into chains along the b axis.
For a review of the biological relevance and synthesis of C-substituted morpholine derivatives, see: Wijtmans et al. (2004 ▶). For applications of morpholine derivatives as drugs, see: Dando & Perry (2004 ▶); Hajos et al. (2004 ▶); Hale et al. (1998 ▶); Versiani et al. (2002 ▶). For agrochemical fungicides and bactericides containing a morpholine skeleton, see: Dieckmann et al. (1993 ▶). For applications of morpholines as chiral auxiliaries in asymmetric synthesis, see: Dave & Sasaki (2004 ▶); Enders et al. (1994 ▶).