Research Article: (2SR,3RS)-Methyl 2-(adamantan-1-yl)-3-phenyl­sulfonyl-3-(pyridin-2-ylsulfan­yl)propano­ate dichloro­methane hemisolvate

Date Published: April 01, 2011

Publisher: International Union of Crystallography

Author(s): Rosa-Luisa Meza-León, Sylvain Bernès, Elsie Ramírez Domínguez, Martha Sosa-Rivadeneyra, Leticia Quintero-Cortés.


The title compound, C25H29NO4S2 0.5CH2Cl2, was obtained as a racemate. The pyridine and phenyl rings are arranged face-to-face, giving a weak intra­molecular π–π inter­action [centroid–centroid separation = 3.759 (3) Å]. These inter­actions are extended inter­molecularly, forming chains of stacked rings along [001] with separations of 3.859 (3) and 3.916 (3) Å. The solvent used for crystallization, CH2Cl2, is located in voids between the chains of mol­ecules, with a site occupancy of 0.5.

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For chemical, polymer and pharmaceutical applications of adamantane and its derivatives, see: Beller et al. (2002 ▶); Mathias et al. (1995 ▶, 2001 ▶); Stotskaya et al. (1995 ▶); Spasov et al. (2000 ▶); Enomoto et al. (2010 ▶). For catalyst reactions, see: Taoufik et al. (1999 ▶). For poly(p-phenyl­ene­vinyl­ene) (PPV) derivatives, see: Jeong et al. (2002 ▶). For their anti­viral and disease-related activity, see: Kadi et al. (2010 ▶); Papanastasiou et al. (2010 ▶) and for their use in the treatment of influenza A, leukemia and deafness, see: Zarubaev et al. (2010 ▶); Spasov et al. (2000 ▶). For the Barton deca­rboxylation reaction, see: Togo (2004 ▶).




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