Research Article: 3β,12β,14α-Trihydroxy­pregnan-20-one

Date Published: May 01, 2009

Publisher: International Union of Crystallography

Author(s): Hefang Shi, Yingxia Li.

http://doi.org/10.1107/S1600536809013853

Abstract

The title compound, C21H34O4, is a steriod of the pregnane family prepared by the sequential oxidation and reduction of 3β,12β-diacet­oxy-20-ethyl­enedioxy­pregnan-14-ene. The con­formations of the six-membered rings are close to chair forms, while the five-membered ring adopts an envelope conformation. All the rings are trans-fused and an intra­molecular O—H⋯O hydrogen bond occurs. In the crystal structure, inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into a two-dimensional network.

Partial Text

For the synthesis, see: Templeton & Yan (1992 ▶); Fell & Heathcock (2002 ▶). For background on hecogenin, see: Ranu & Samanta (2003 ▶).

Source:

http://doi.org/10.1107/S1600536809013853