Research Article: 3-[(1-Hy­droxy-1-phenyl­propan-2-yl)amino]-5,5-dimethyl­cyclo­hex-2-enone

Date Published: May 01, 2012

Publisher: International Union of Crystallography

Author(s): Mostafa M. Ghorab, Mansour S. Al-Said, Saleh I. Alqasoumi, Tze Shyang Chia, Hoong-Kun Fun.


The asymmetric unit of the title compound, C17H23NO2, consists of two crystallographically independent mol­ecules (A and B). The cyclo­hexene rings in both mol­ecules adopt an envelope conformation. In the crystal, independent mol­ecules, A and B, are each linked by inter­molecular bifurcated (N,O)—H⋯O hydrogen bonds, generating R21(7) ring motifs and forming infinite chains along the b axis.

Partial Text

For cyclo­hex-2-enone derivatives and their biological activity, see: Ghorab et al. (2009 ▶, 2010 ▶); Ghorab, Al-Said & El-Hossary (2011 ▶); Aghil et al. (1992 ▶); Li & Strobel (2001 ▶). For the biological activity of phenyl­propan-2-yl­amino, see: Zhang et al. (2011 ▶). For the synthesis of biologically active heterocyclic compounds, see: Ghorab et al. (2012 ▶); Ghorab, Ragab et al. (2011 ▶). For hydrogen-bond motifs, see: Bernstein et al. (1995 ▶). For ring conformations, see: Cremer & Pople (1975 ▶).