Date Published: May 01, 2012
Publisher: International Union of Crystallography
Author(s): Ju Liu, Zhi-Qiang Cai, Yang Wang, Ming-Jun Jiang, Li-Feng Xu.
In the title compound, C20H11Cl2F4N3, the central pyrazolo[1,5-a]pyrimidine unit is almost planar [the mean deviation from the best least-square plane through the nine atoms is 0.006 (2) Å]. The fluorobenzene ring is rotated out of this plane by 10.3 (3)°, whereas the dichlorobenzene ring is rotated by 46.2 (3)°. The crystal packing is dominated by Cl⋯Cl interactions of 3.475 (3) Å and van der Waals interactions.
For the synthesis of other pyrazolo[1,5-a]pyrimidine derivatives and for their pharmacological applications, see: Fraley et al. (2012 ▶); Novinson et al. (1976 ▶); Senga et al. (1981 ▶); Suzuki et al. (2001 ▶). For related structures, see: Liu et al. (2012 ▶); Bui et al. (2009 ▶).