Research Article: 3-(2,4-Dichloro­phen­yl)-5-(4-fluoro­phen­yl)-2-methyl-7-(trifluoro­meth­yl)pyrazolo­[1,5-a]pyrimidine

Date Published: May 01, 2012

Publisher: International Union of Crystallography

Author(s): Ju Liu, Zhi-Qiang Cai, Yang Wang, Ming-Jun Jiang, Li-Feng Xu.


In the title compound, C20H11Cl2F4N3, the central pyrazolo­[1,5-a]pyrimidine unit is almost planar [the mean deviation from the best least-square plane through the nine atoms is 0.006 (2) Å]. The fluoro­benzene ring is rotated out of this plane by 10.3 (3)°, whereas the dichloro­benzene ring is rotated by 46.2 (3)°. The crystal packing is dominated by Cl⋯Cl inter­actions of 3.475 (3) Å and van der Waals inter­actions.

Partial Text

For the synthesis of other pyrazolo­[1,5-a]pyrimidine derivatives and for their pharmacological applications, see: Fraley et al. (2012 ▶); Novinson et al. (1976 ▶); Senga et al. (1981 ▶); Suzuki et al. (2001 ▶). For related structures, see: Liu et al. (2012 ▶); Bui et al. (2009 ▶).