Research Article: 3-(4-Chloro­phen­yl)-1-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octa­hydro­naphthalen-2-yl]prop-2-en-1-one

Date Published: June 01, 2011

Publisher: International Union of Crystallography

Author(s): Mohamed Tebbaa, Ahmed Benharref, Moha Berraho, Daniel Avignant, Abdelghani Oudahmane, Mohamed Akssira.

http://doi.org/10.1107/S1600536811016886

Abstract

The title compound, C21H25ClO, was semi-synthesized from isocostic acid, isolated from the aerial part of Inula Viscosa­ (L) Aiton [or Dittrichia Viscosa­ (L) Greuter]. The cyclo­hexene ring has a half-chair conformation, whereas the cyclo­hexane ring displays a chair conformation.

Partial Text

For background to the medicinal inter­est in Inula Viscosa­ (L) Aiton [or Dittrichia Viscosa­ (L) Greuter], see: Shtacher & Kasshman (1970 ▶); Bohlman & Gupta (1982 ▶); Azoulay et al. (1986 ▶); Bohlman et al. (1977 ▶); Ceccherelli et al. (1988 ▶). For the synthesis, see: Kutney & Singh (1984 ▶). For conformational analysis, see: Cremer & Pople (1975 ▶).

 

Source:

http://doi.org/10.1107/S1600536811016886

 

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