Date Published: June 01, 2012
Publisher: International Union of Crystallography
Author(s): Ali A. El-Emam, Mohamed A. Al-Omar, Abdul-Malek S. Al-Tamimi, Seik Weng Ng, Edward R. T. Tiekink.
The asymmetric unit of the title dichloromethane hemisolvate, C24H33N5S·0.5CH2Cl2, comprises an adamantanyl/triazole derivative and half a CH2Cl2 molecule of crystallization; the latter is disordered about a twofold axis of symmetry. The piperazine ring has a chair conformation and the two N-bound substituents occupy equatorial positions. The piperazine residue is almost normal to the triazole ring [N—N—C—N torsion angle = −79.9 (3)°] so that to a first approximation, the molecule has an L-shape. Linear supramolecular chains parallel to  are formed via C—H⋯S interactions. Two such chains are linked into a double chain via C—H⋯Cl interactions involving the disordered CH2Cl2 molecules of solvation.
For the diverse biological activities of adamantane derivatives, see: Al-Deeb et al. (2006 ▶); Al-Omar et al. (2010 ▶). For related adamantanyl structural studies, see: El-Emam et al. (2012a ▶,b ▶). For the preparation of one of the precursor molecules, see: El-Emam & Ibrahim (1991 ▶).