Date Published: July 01, 2012
Publisher: International Union of Crystallography
Author(s): Sammer Yousuf, Syed M. Younas, Nida Ambreen, Khalid M. Khan, Ghulam A. Miana.
The title compound, C21H24N2O2, is a phenyl hydrazine derivative of the well known anthelminthic agent α-santonin, which is composed of three fused rings (benzodieneone, cyclohexane and γ-lactone). The cyclohexadienone ring adopts a boat conformation, the cyclohexane ring is in a chair conformation and the trans-fused γ-lactone ring adopts a C-envelope conformation. In the crystal, molecules are linked by N—H⋯O and C—H⋯O hydrogen bonds, forming chains along the a axis.
For the isolation of α-santonin, see: Kahler (1830 ▶). For the crystal structure and stereochemistry of α-santonin, see: White & Sim (1975 ▶); Coggon & Sim (1969 ▶). For puckering parameters, see: Cremer & Pople (1981 ▶).