Research Article: (3,6-Dimethyl-1,2,4,5-tetra­zine-1,4-di­yl)bis­[(morpholin-4-yl)methanone]

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Na-Bo Sun, Yan-Mei Guo, Guo-Wu Rao.

http://doi.org/10.1107/S1600536812004849

Abstract

In the title mol­ecule, C14H22N6O4, the amide-substituted N atoms of the tetra­zine ring deviate from the approximate plane of the four other atoms in the ring by 0.160 (2) and 0.243 (2) Å, forming a slight boat conformation. The morpholine rings are in chair conformations.

Partial Text

For chemical reactions of 1,2,4,5-tetra­zine derivatives, see: Domingo et al. (2009 ▶); Lorincz et al. (2010 ▶). For their bio­logical activities, see: Devaraj et al. (2009 ▶); Eremeev et al. (1978 ▶, 1980 ▶); Han et al. (2010 ▶); Neunhoeffer (1984 ▶); Sauer (1996 ▶). For anti-tumor activity of 1,2,4,5-tetra­zine derivatives, see: Hu et al. (2002 ▶, 2004 ▶); Rao & Hu, (2005 ▶, 2006 ▶). For details of the synthesis, see: Hu et al. (2004 ▶); Skorianetz & Kováts (1970 ▶, 1971 ▶); Sun et al. (2003 ▶). For standard bond lengths, see: Allen et al. (1987 ▶).

 

Source:

http://doi.org/10.1107/S1600536812004849